tag:blogger.com,1999:blog-74467205734120950162024-02-21T01:20:59.583-06:00The Tech Savvy PatientWe look at how personal technology fits into today's and tomorrow's healthcare.Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.comBlogger222125tag:blogger.com,1999:blog-7446720573412095016.post-37016295492550108262015-05-20T10:36:00.001-05:002015-05-20T10:36:24.546-05:00I think therefore I move<p> http://www.reuters.com/article/2015/05/20/us-iceland-mind-controlled-limb-idUSKBN0O51EQ20150520</p><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-44890495731706643282015-01-27T11:02:00.001-06:002015-01-27T11:02:48.770-06:00breathing-for-your-better-healthhttp://www.wsj.com/articles/breathing-for-your-better-health-1422311283?tesla=y<div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-31677147627786359062015-01-05T13:19:00.001-06:002015-01-05T13:19:35.927-06:00An interesting concept Doctor on Demand<p> http://recode.net/video/katie-reviews-doctor-on-demand/</p><p> </p><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-50124973771545198772015-01-04T13:29:00.001-06:002015-01-04T13:29:06.418-06:00A Stethoscope for the Next 200 Year
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<p>I thought you would be interested in the following story from The Wall Street Journal. It looks at some tremendous new specific disease diagnostics that are not horribly expensive.</p>
<p>A Stethoscope for the Next 200 Years</p>
<p>http://online.wsj.com/articles/eric-topol-and-stephen-r-quake-a-stethoscope-for-the-next-200-years-1420242913 </p>
<div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-56595998392055415202014-09-16T01:27:00.001-05:002014-09-16T01:27:27.094-05:00Should You Get Cancer Screenings?
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<span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; font-weight: normal; font-size: 18px; line-height: 1.3em;">by</span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; font-weight: normal; font-size: 18px; line-height: 1.3em;"> </span><a class="RIL_author" href="http://topics.wsj.com/person/A/biography/1255" style="-webkit-text-size-adjust: auto; font-size: 18px; line-height: 1.3em; margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">MELINDA BECK</a><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; font-weight: normal; font-size: 18px; line-height: 1.3em;">,</span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; font-weight: normal; font-size: 18px; line-height: 1.3em;"> </span><a href="http://online.wsj.com/" style="-webkit-text-size-adjust: auto; font-weight: normal; font-size: 18px; line-height: 1.3em; margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">online.wsj.com</a><br>
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<p nodeindex="204" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Does the risk of overdiagnosis mean people should stop getting cancer screenings?</span></p>
<p nodeindex="205" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Doctors on both sides of the debate increasingly say patients should weigh all the pros and cons—including their health, age, family history and tolerance for uncertainty—and decide for themselves.</span></p>
<p nodeindex="206" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">That may sound obvious, but the concept of "shared decision-making" is still relatively new in cancer care. Some hospitals have started programs to implement it.</span></p>
<p nodeindex="207" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Proponents say shared decision-making requires doctors to be more candid about the upsides, downsides and unknowns of both screening and treating early-stage cancers.</span></p>
<p nodeindex="208" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"We in our health-care conversations have not adequately explained both sides," says Otis Brawley, chief medical officer of the American Cancer Society. For example, he says, mammograms do save lives, but not as many as most people think. For women in their 60s, regular screenings reduce the risk of dying of breast cancer by about 30%. "But 70% of women who were going to die of breast cancer will still die of it," Dr. Brawley says.</span></p>
<p nodeindex="219" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Patients often overestimate the lifetime risk of dying of cancer, he says. For prostate cancer and for breast cancer, it's about 2.7%. Put another way, for every 10,000 women in their 60s screened annually for 10 years, between five and 49 breast-cancer deaths will be averted; about 90 women will die of breast cancer anyway and 64 to 194 will be treated unnecessarily, according to a recent analysis in JAMA. An additional 940 will have biopsies that find no cancer.</span></p>
<p nodeindex="220" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">For some patients, lowering even a small risk of dying of cancer is worth undergoing frequent screening and aggressively treating even low-risk cancers. Many cancer survivors say they are glad their cancer was found early, and don't second-guess if it needed to be caught at all. Some say they'd rather know they have even a low-risk cancer than stop looking and be left to wonder.</span></p>
<p nodeindex="221" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"Knowledge is empowering—you don't have to act on it, but you should keep an eye on it," says Gary Bloom of Olney, Md., who was treated for an aggressive papillary thyroid cancer 19 years ago.</span></p>
<p nodeindex="222" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Official screening guidelines, meanwhile, are moving away from one-size-fits-all recommendations and are telling patients to consult their doctors.</span></p>
<p nodeindex="223" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">That takes more time, but doctors say it's the best way to manage uncertain risks and myriad human emotions.</span></p>
<p nodeindex="224" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Says dermatologist Brett Coldiron : "The era of paternalistic medicine is over."</span></p>
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<div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-8721377644243923542014-09-02T19:51:00.001-05:002014-09-02T19:51:10.904-05:00A new possible treatment for Glacoma<p> </p><p> </p><p> http://online.wsj.com/articles/needle-treatment-for-glaucoma-shows-promise-1407193884?tesla=y&mod=djemHL_t&mg=reno64-wsj&url=http://online.wsj.com/article/SB10001424052702304635104580065533577612228.html?mod=djemHL_t</p><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-88476786816512448032014-08-27T14:43:00.001-05:002014-08-27T14:43:54.729-05:00The Secret To Creativity, Intelligence, And Scientific Thinking<p> </p><p id="RIL_header" style="padding-bottom: 1.5em;"><cite style="margin: 0px 0px 25px; padding: 0px; position: relative; display: block;"><span class="ril_byline_content" style="margin: 0px; padding: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">fastcompany<a href="http://fastcompany.com/" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">.com</a></span><br></cite></p><p id="RIL_body" style="clear: both;"><div id="RIL_less"><div lang="en"><header nodeindex="89" style="margin: 0px; padding: 0px;"><div class="summary row collapse" nodeindex="88"><div class="deck" itemprop="deck description" nodeindex="91"><p nodeindex="92" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Research shows that creativity and intelligence are linked with the physical connections in our brains. Here's how to connect the dots.</span></p></p></div></header><div class="row collapse" nodeindex="98"><div class="body prose article-prose twelve columns" itemprop="body" nodeindex="100"><p nodeindex="101" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">There’s a key difference between knowledge and experience and it’s best described like this:</span></p><figure class="inline-large inline" nodeindex="103" style="margin: 0px; padding: 0px;"></figure><p nodeindex="104" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The image is from <a href="https://twitter.com/gapingvoid/statuses/423952995240648704" target="_blank" nodeindex="467" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">cartoonist Hugh MacLeod</a>, who came up with such a brilliant way to express a concept that’s often not that easy to grasp.</span></p><p nodeindex="105" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The image makes a clear point—that knowledge alone is not useful <a href="http://blog.bufferapp.com/why-we-have-our-best-ideas-in-the-shower-the-science-of-creativity" target="_blank" nodeindex="468" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">unless we can make connections</a> between what we know. Whether you use the terms “knowledge” and “experience” to explain the difference or not, the concept itself is sound.</span></p><p nodeindex="106" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Lots of great writers, artists and scientists <a href="http://blog.bufferapp.com/the-daily-routines-of-famous-entrepreneurs-and-how-to-design-your-own-master-routine" target="_blank" nodeindex="469" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">have talked about the importance of collecting ideas</a> and bits of knowledge from the world around us, and making connections between those dots to fuel creative thinking and new ideas.</span></p><p nodeindex="107" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">This is a really fun, inspiring topic to read about, so I <a href="http://blog.bufferapp.com/the-daily-routines-of-famous-entrepreneurs-and-how-to-design-your-own-master-routine" target="_blank" nodeindex="470" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">collected some quotes</a> and advice from my favorite creative thinkers about the importance of making connections in your brain. I’ve added emphasis to the important parts, but if you have time I’d recommend reading the whole post and even digging into the sources I’ve linked to.</span></p><p nodeindex="108" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">To start with though, I want to look at some research that shows intelligence is closely linked with the physical connections in our brains.</span></p><h4 nodeindex="471" style="margin-top: 1.7em; margin-bottom: 0.5em; padding-bottom: 0px;"><a name="Intelligence_and_connections_why_your_brain_needs_to_communicate_well_with_itself" nodeindex="472" style="margin: 0px; padding: 0px; cursor: pointer; line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font size="4">Intelligence and connections: why your brain needs to communicate well with itself</font></a></h4><p nodeindex="109" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><font color="#000000"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><a href="http://www.sciencedaily.com/releases/2010/02/100222161843.htm" target="_blank" nodeindex="473" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">Research from the California Institute of Technology</a> showed that intelligence is something found all across the brain, rather than in one specific region:</span></font></p><blockquote nodeindex="110"><p nodeindex="111" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The researchers found that, rather than residing in a single structure, general intelligence is determined by a network of regions across both sides of the brain.</span></p></blockquote><p nodeindex="112" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">One of the researchers explained that the study showed the brain working as a distributed system:</span></p><blockquote nodeindex="113"><p nodeindex="114" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">“Several brain regions, and the connections between them, were what was most important to general intelligence,” explains Gläscher.</span></p></blockquote><p nodeindex="115" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The study also supported an existing theory about intelligence that says general intelligence is based on the brain’s ability to pull together and integrate various kinds of processing, such as working memory.</span></p><p nodeindex="116" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">At Washington University, a <a href="https://news.wustl.edu/news/Pages/24068.aspx" target="_blank" nodeindex="474" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">research study</a> found that connectivity with a particular area of the prefrontal cortex has a correlation with a person’s general intelligence.</span></p><p nodeindex="117" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">This study showed that intelligence relied partly on high functioning brain areas, and partly on their ability to communicate with other areas in the brain.</span></p><p nodeindex="118" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Aside from physical connectivity in the brain, being able to make <a href="http://blog.bufferapp.com/how-to-never-forget-the-name-of-someone-you-just-met-the-science-of-memorization" target="_blank" nodeindex="475" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">connections between ideas and knowledge</a>we hold in our memories can help us to think more creatively and produce higher quality work.</span></p><figure class="inline-small inline" nodeindex="120" style="margin: 0px; padding: 0px;"></figure><h4 nodeindex="476" style="margin-top: 1.7em; margin-bottom: 0.5em; padding-bottom: 0px;"><a name="Connections_fuel_creativity_nothing_is_original" nodeindex="477" style="margin: 0px; padding: 0px; cursor: pointer; line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font size="4">Connections fuel creativity: nothing is original</font></a></h4><p nodeindex="121" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Steve Jobs is an obvious person to reference whenever you’re talking about <a href="http://blog.bufferapp.com/why-we-have-our-best-ideas-in-the-shower-the-science-of-creativity" target="_blank" nodeindex="478" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">creativity or innovation</a>, so I wasn’t surprised to find that he has spoken about making connections before. This great quote is from a<em nodeindex="479" style="margin: 0px; padding: 0px;">Wired</em> interview in 1996:</span></p><blockquote nodeindex="122"><p nodeindex="123" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Creativity is just connecting things. When you ask creative people how they did something, they feel a little guilty because they didn’t really do it, they just saw something.</span></p></blockquote><p nodeindex="124" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Jobs went on to explain that experience (as we saw in the image at the top of this post) is the secret to <a href="http://blog.bufferapp.com/5-ways-to-be-a-better-reader-and-improve-your-writing-in-the-process" target="_blank" nodeindex="480" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">being able to make connections so readily</a>:</span></p><blockquote nodeindex="125"><p nodeindex="126" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">That’s because they were able to connect experiences they’ve had and synthesize new things. And the reason they were able to do that was that they’ve had more experiences or they have thought more about their experiences than other people.<br nodeindex="481" style="margin: 0px; padding: 0px;"></span></p></blockquote><figure class="inline-small inline" nodeindex="482" style="margin: 0px; padding: 0px;"></figure><p nodeindex="127" style="margin-bottom: 1em; text-align: justify; -webkit-hyphens: auto;"><font color="#000000"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><a href="http://www.fastcompany.com/person/maria-popova" class="fc-plugin people-page" data-name="peoplePages" data-id="fastcompany|node|3020483" nodeindex="483" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;"></a></span></font></p><font color="#000000"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><a href="http://www.fastcompany.com/person/maria-popova" class="fc-plugin people-page" data-name="peoplePages" data-id="fastcompany|node|3020483" nodeindex="483" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">Maria Popova</a> is arguably one of the best examples (and <a href="http://www.brainpickings.org/index.php/2011/08/01/networked-knowledge-combinatorial-creativity/" target="_blank" nodeindex="484" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">proponents</a>) of what she calls “<a href="http://blog.bufferapp.com/why-we-have-our-best-ideas-in-the-shower-the-science-of-creativity" target="_blank" nodeindex="485" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">combinatorial creativity</a>.” That is, connecting things to create new ideas:</span></font><blockquote nodeindex="128"><p nodeindex="129" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">… in order for us to truly create and contribute to the world, we have to be able to connect countless dots, to cross-pollinate ideas from a wealth of disciplines, to combine and recombine these pieces and build new castles.</span></p></blockquote><p nodeindex="130" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">She’s given a talk on this at a <a href="http://www.brainpickings.org/index.php/2011/08/01/networked-knowledge-combinatorial-creativity/" target="_blank" nodeindex="486" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">Creative Mornings event</a> before, and made some great points. Being able to read about a wide range of topics is often one of of the most important elements. I really liked how she pointed out the way our egos affect our willingness to build on what others have done before:</span></p><blockquote nodeindex="131"><p nodeindex="132" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">… something we all understand on a deep intuitive level, but our creative egos sort of don’t really want to accept: And that is the idea that creativity is combinatorial, that nothing is entirely original, that everything builds on what came before…</span></p></blockquote><p nodeindex="133" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">My favorite part of this talk is Popova’s Lego analogy, where she likens the dots of knowledge we have to Lego building blocks:</span></p><blockquote nodeindex="134"><p nodeindex="135" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The more of these building blocks we have, and the more diverse their shapes and colors, the more interesting our castles will become.</span></p></blockquote><figure class="inline-small inline" nodeindex="487" style="margin: 0px; padding: 0px;"></figure><p nodeindex="136" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Author <a href="http://www.fastcompany.com/person/austin-kleon" class="profile" nodeindex="488" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">Austin Kleon</a> is someone who immediately comes to mind whenever the topic of connections and remixing art comes up. Kleon is the author of <em nodeindex="489" style="margin: 0px; padding: 0px;"><a href="http://www.amazon.com/dp/B0074QGGK6/ref%3Dr_soa_w_d?&tag=rnwap-20" target="_blank" nodeindex="490" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">Steal Like An Artist</a></em>, a book about using the work of others to inspire and inform your own.</span></p><p nodeindex="137" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">It starts off like this:</span></p><blockquote nodeindex="138"><p nodeindex="139" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Every artist gets asked the question, “Where do you get your ideas?”</span></p><p nodeindex="140" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The honest artist answers, “I steal them.”</span></p></blockquote><p nodeindex="141" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Kleon is inspiring because he’s so upfront about how the work of other people has become part of his own work. He’s also keen on the phrase I quoted from Maria Popova above, that “nothing is original”:</span></p><p nodeindex="142" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Every new idea is just a mashup or a remix of one or more previous ideas.</span></p><p nodeindex="143" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">If you’re looking for advice on creating more connections between the knowledge you have (and collecting even more knowledge), Kleon’s book is a great place to start. He offers suggests like:</span></p><ul nodeindex="145" style="margin-top: 1.5em; margin-bottom: 1.5em; margin-left: 2em; padding-left: 0px;"><li nodeindex="144" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span nodeindex="491" style="margin: 0px; padding: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">carry a notebook everywhere</span></li><li nodeindex="146" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span nodeindex="492" style="margin: 0px; padding: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">read a lot</span></li><li nodeindex="147" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span nodeindex="493" style="margin: 0px; padding: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">keep a <a href="https://medium.com/the-writers-room/8d6e7df7ae58" target="_blank" nodeindex="494" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">scratch file</a></span></li></ul><h4 nodeindex="495" style="margin-top: 1.7em; margin-bottom: 0.5em; padding-bottom: 0px;"><a name="How_scientific_thinking_is_all_about_making_connections" nodeindex="496" style="margin: 0px; padding: 0px; cursor: pointer; line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font size="4">How scientific thinking is all about making connections</font></a></h4><p nodeindex="148" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">When it comes to the field of science, making connections between those dots of knowledge seems to be just as important. In <em nodeindex="497" style="margin: 0px; padding: 0px;"><a href="http://www.brainpickings.org/index.php/2012/05/25/the-art-of-scientific-investigation-1/" target="_blank" nodeindex="498" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">The Art of Scientific Investigation</a></em>, Cambridge University professor W. I. B. Beveridge wrote that successful scientists “have often been people with wide interests,” which led to their originality:</span></p><blockquote nodeindex="149"><p nodeindex="150" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Originality often consists in linking up ideas whose connection was not previously suspected.</span></p></blockquote><p nodeindex="151" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">He also suggested that <a href="http://blog.bufferapp.com/5-ways-to-be-a-better-reader-and-improve-your-writing-in-the-process" target="_blank" nodeindex="499" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">scientists should expand their reading</a> outside of their own field, in order to add to their knowledge (so they would have more dots when it came time to connect them, later):</span></p><blockquote nodeindex="152"><p nodeindex="153" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Most scientists consider that it is a more serious handicap to investigate a problem in ignorance of what is already known about it.</span></p></blockquote><figure class="inline-small inline" nodeindex="500" style="margin: 0px; padding: 0px;"></figure><p nodeindex="154" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Lastly, science writer Dorian Sagan agrees that <a href="http://www.brainpickings.org/index.php/2013/04/30/dorion-sagan-cosmic-apprentice/" target="_blank" nodeindex="501" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">science is about connections</a>:</span></p><blockquote nodeindex="155"><p nodeindex="156" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Nature no more obeys the territorial divisions of scientific academic disciplines than do continents appear from space to be colored to reflect the national divisions of their human inhabitants. For me, the great scientific satoris, epiphanies, eurekas, and aha! moments are characterized by their ability to connect.</span></p></blockquote><h4 nodeindex="502" style="margin-top: 1.7em; margin-bottom: 0.5em; padding-bottom: 0px;"><a name="Start_making_connections_and_getting_creative" nodeindex="503" style="margin: 0px; padding: 0px; cursor: pointer; line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font size="4">Start making connections and getting creative</font></a></h4><p nodeindex="157" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">I’ll leave you with some suggestions for improving your own ability to make connections.</span></p><h4 nodeindex="504" style="margin-top: 1.7em; margin-bottom: 0.5em; padding-bottom: 0px;"><a name="1_Add_to_your_knowledgethe_power_of_brand_new_experiences" nodeindex="505" style="margin: 0px; padding: 0px; cursor: pointer; line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font size="4">1. Add to your knowledge--the power of brand new experiences</font></a></h4><p nodeindex="158" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">After all, the more knowledge you have, the more connections you can make. Start by reading more, reading more widely, and exploring new opportunities for gathering knowledge (for instance, try some new experiences—travel, go to meetups or take up a new hobby).</span></p><p nodeindex="159" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">As researcher Dr.Duezel explained when it comes to experiencing new things:</span></p><blockquote nodeindex="160"><p nodeindex="161" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">“Only completely new things cause strong activity in the midbrain area.”</span></p></blockquote><p nodeindex="162" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">So trying something new and forcing a gentle brain overload can make a <a href="http://blog.bufferapp.com/novelty-and-the-brain-how-to-learn-more-and-improve-your-memory" target="_blank" nodeindex="506" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">dramatic improvement</a> for your brain activity.</span></p><h4 nodeindex="507" style="margin-top: 1.7em; margin-bottom: 0.5em; padding-bottom: 0px;"><a name="2_Keep_track_of_everything__especially_in_the_shower" nodeindex="508" style="margin: 0px; padding: 0px; cursor: pointer; line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font size="4">2. Keep track of everything – especially in the shower</font></a></h4><p nodeindex="163" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">As Austin Kleon suggests, take a notebook (or your phone) with you everywhere and take notes. Don’t expect your brain to remember everything--give it a hand by noting down important concepts or ideas you come across. As you do this, you may remember previous notes that relate (hey, you’re making connections already!)--make a note of those as well.</span></p><p nodeindex="164" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">You can do this even when you’re in the shower with something like Acqua Notes. The shower is <a href="http://blog.bufferapp.com/why-we-have-our-best-ideas-in-the-shower-the-science-of-creativity" target="_blank" nodeindex="509" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">especially a place</a> that has proven to make us more creative.</span></p><figure class="inline-large inline" nodeindex="166" style="margin: 0px; padding: 0px;"></figure><h4 nodeindex="510" style="margin-top: 1.7em; margin-bottom: 0.5em; padding-bottom: 0px;"><font size="4"><span style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><a name="3_Review_your_notes_dailythe_urlhttpblogbufferappcomthedailyroutinesoffamousentrepreneursandhowtodesignyourownmasterroutineBenjamin_Franklin_methodurl" nodeindex="511" style="margin: 0px; padding: 0px; cursor: pointer;">3. Review your notes daily--the </a><a href="http://blog.bufferapp.com/the-daily-routines-of-famous-entrepreneurs-and-how-to-design-your-own-master-routine" target="_blank" nodeindex="512" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">Benjamin Franklin method</a></span></font></h4><p nodeindex="167" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Going over your notes often can help you to more easily recall them when you need to. Read through what you’ve made notes of before, and you might find that in the time that’s passed, you’ve added more knowledge to your repertoire that you can now connect to your old notes!</span></p><p nodeindex="168" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In fact, this used to be <a href="http://blog.bufferapp.com/the-daily-routines-of-famous-entrepreneurs-and-how-to-design-your-own-master-routine" target="_blank" nodeindex="513" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">one of Benjamin Franklin’s best kept secrets</a>. Every morning and every evening he would review his day answering 1 simple question:</span></p><p nodeindex="169" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">“What good have I done today?”</span></p><p nodeindex="170" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Here is his <a href="http://blog.bufferapp.com/the-daily-routines-of-famous-entrepreneurs-and-how-to-design-your-own-master-routine" target="_blank" nodeindex="514" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">original daily routine</a> from way back:</span></p><figure class="inline-large inline" nodeindex="172" style="margin: 0px; padding: 0px;"></figure><p nodeindex="173" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">No doubt you have some great ideas of your own--let us know in the comments what works for you.</span></p><p nodeindex="174" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><em nodeindex="515" style="margin: 0px; padding: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">This article <a href="http://blog.bufferapp.com/connections-in-the-brain-understanding-creativity-and-intelligenceconnections" target="_blank" nodeindex="516" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">originally appeared on Buffer</a> and is reprinted with permission.</em></p></div></div></div></div></div><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-55867121552102264592014-08-21T15:15:00.001-05:002014-08-21T15:15:01.909-05:00The golden age of Neuroscience and what it may mean to you
<p> </p>
<p>This is a great article about the gains that are being made in what goes on between your ears.</p>
<p> <a href="http://online.wsj.com/articles/michio-kaku-the-golden-age-of-neuroscience-has-arrived-1408577023" style="line-height: 1.3em;">http://online.wsj.com/articles/michio-kaku-the-golden-age-of-neuroscience-has-arrived-1408577023</a></p>
<div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-17299678727558627432014-08-20T20:51:00.001-05:002014-08-20T20:51:18.506-05:00Bacterial Robotics building “bactobots” engineered to destroy skull-based tumors
<p> <span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;"> </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;">August 12, 2014 at 5:55 am</span></p>
<p class="author" style="border: 0px; outline: 0px; vertical-align: baseline; display: inline; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><span class="icon-user" style="border: 0px; outline: 0px; vertical-align: baseline; margin: 0px; padding: 0px; text-decoration: inherit; -webkit-font-smoothing: antialiased; display: inline; width: auto; height: auto; background-image: none; background-position: 0% 0%; background-repeat: repeat repeat;"></span> Written by Meghana Keshavan</p>
<p class="wptouch-custom-ad" style="border: 0px; outline: 0px; vertical-align: baseline; margin: 10px; text-align: center;"></p>
<p style="text-align: start;"> <span style="text-align: start; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Cincinnati-based Bacterial Robotics is engineering a legion of so-called "bactobots" to do our bidding – in the fields of health care, industrial waste management and a litany of others.</span></p>
<p style="text-align: start;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">It just received National Science Foundation funding to further develop its bacteria that can be used as a surgical tool. It is developing an organism that recognizes a certain type of <a href="http://bacterialrobotics.com/2014/07/15/bacterial-robotics-reports-research-findings-tumor-surgical-product/" style="border: 0px; outline: 0px; vertical-align: baseline; margin: 0px; padding: 0px; text-decoration: none;">skull-based tumor called a cholesteatoma</a> that often leads to meningitis, brain abscess and death.</span></p>
<p style="text-align: start;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"Our goal is to inject the bactobot into the tumor, and have it recognize the tumor as a feedstock – and then destroy the tumor," CEO Jason Barkeloo said.</span></p>
<p style="text-align: start;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Code-named the Auribot, the engineered bacterium is being developed to augment current skull-based surgical practices, he said. It gives surgeons a consumable product that uses lysis to destroy residual cholesteatoma cells after the primary skull-based surgery is complete, he said.</span></p>
<p style="text-align: start;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The synthetic biology company is focused on taking natural genes – the genes that allow organisms to complete any given task in a natural setting – and move them into an "industrially robust bacteria," Barkeloo said.</span></p>
<p style="text-align: start;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"These little bacterial robots can do anything – produce biofuels, work as surgical devices, clean water – anything you can imagine a bacterium to do," Barkeloo said. "We’re working on one that strips paint off a wall."</span></p>
<p style="text-align: start;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The small company sold its first subsidiary, Pilus Energy, last year to San Diego-based <a href="http://www.taurigasciences.com/" style="border: 0px; outline: 0px; vertical-align: baseline; margin: 0px; padding: 0px; text-decoration: none;">Tauriga Sciences</a> for $2.5 million. The bactobot it delivered cleans industrial customer waste.</span></p>
<p style="text-align: start;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The company’s business model involves developing these bactobots but then handing over further research and commercialization efforts to market experts.</span></p>
<p style="text-align: start;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"We’re able to launch a lot more bactobots then," Barkeloo said. "We’re not a cradle-to-grave company – maybe more of a cradle-to-diapers one."</span></p>
<div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-27867693084368743562014-07-26T17:06:00.001-05:002014-07-26T17:06:20.404-05:00The operating room of the future<p>A fascinating video about tomorrow's surgery.</p><p> http://safeshare.tv/w/DTAINyElxY</p><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-35051260255011760542014-07-14T15:56:00.001-05:002014-07-14T15:56:48.640-05:00This is some very amazing discoveries that you will find most interesting.<p> <strong><span lang="EN-AU" style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Top 10 Israeli medical advances to watch in 2014 | ISRAEL21c</span></strong></p><p class="gmail_quote"><div dir="ltr"><div class="gmail_quote"><div><div><div><div><div><div><div><div><span lang="EN-AU" style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"> <br>ISRAEL21c compiles a list of the 10 most extraordinary medical devices and pharmaceuticals that promise to revolutionize global healthcare.<br><br><strong>Prof. Hossam Haick with the Na-Nose prototype.<br></strong> <br>We promised a top 10 list of the most exciting Israeli medical-device and pharmaceutical developments just around the corner. This list was very difficult to narrow down, because Israeli breakthroughs in this field are a near-daily occurrence. Our top 10 is just the tip of the iceberg....</span></p><p><span lang="EN-AU" style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"> </span></p><p><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><span lang="EN-AU"><br></span><span lang="EN-AU"><br><br><strong>1. Na-Nose <a title="http://israel21c.org/health/the-nose-that-can-smell-cancer-goes-commercial" href="http://israel21c.org/health/the-nose-that-can-smell-cancer-goes-commercial" rel="nofollow" target="_blank">http://israel21c.org/health/the-nose-that-can-smell-cancer-goes-commercial</a> </strong>can detect lung cancer from exhaled breath and will be commercialized in a joint venture with Boston-based Alpha Szenszor – after a few more years of development and testing by the US Food and Drug Administration (FDA). Invented by Technion Prof. Hossam Haick, Na-Nose (the “na” is for “nanotechnology”) has been proven in numerous international clinical trials to differentiate between different types and classifications of cancer with up to 95 percent accuracy.</span></span></p><p><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><span lang="EN-AU"><br><strong>2. Hervana http://<a title="http://israel21c.org/health/israeli-birth-control-product-wins-gates-grant/" href="http://israel21c.org/health/israeli-birth-control-product-wins-gates-grant/" rel="nofollow" target="_blank">israel21c.org/health/israeli-birth-control-product-wins-gates-grant/</a> </strong>non-hormonal, long-acting contraceptive suppository won a $1 million development grant last year from the Bill & Melinda Gates Foundation. The Gates Foundation is banking on the product’s potential to provide a more accessible, cheaper and socially acceptable family planning option in developing countries, though it would be marketed in the United States and Europe </span><span lang="EN-AU">.</span></span></p><p><span lang="EN-AU" style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"> </span></p><p><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><span lang="EN-AU"><br><strong>3. Vecoy Nanomedicines <a title="http://israel21c.org/health/new-israeli-tactic-makes-deadly-viruses-commit-suicide" href="http://israel21c.org/health/new-israeli-tactic-makes-deadly-viruses-commit-suicide" rel="nofollow" target="_blank">http://israel21c.org/health/new-israeli-tactic-makes-deadly-viruses-commit-suicide</a></strong> nano-scale virus-traps (“vecoys”) capture and destroy viruses before they can infect cells, offering a huge advance over antiviral medications and even vaccines. Through the MassChallenge startup accelerator program last November, Vecoy’s platform was chosen to be tested in zero-gravity conditions on an upcoming NASA space mission.<br></span><span lang="EN-AU"><br> <br><strong>4. CartiHeal <a title="http://israel21c.org/health/good-news-for-knees" href="http://israel21c.org/health/good-news-for-knees" rel="nofollow" target="_blank">http://israel21c.org/health/good-news-for-knees</a> </strong>Agili-C cartilage regeneration solution for knees can regenerate true hyaline cartilage (the most abundant type of cartilage in the human body) after six months, according to clinical results so far. Based on research at Ben-Gurion University of the Negev, the implant has earned the European Union’s CE Mark of approval. Further clinical studies could lead to FDA approval in the coming years.</span></span></p><p><span lang="EN-AU" style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"> </span></p><p><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><span lang="EN-AU"><br><strong>5. Oramed Pharmaceuticals<a title="http://israel21c.org/headlines/groundbreaking-insulin-pill-nearing-market" href="http://israel21c.org/headlines/groundbreaking-insulin-pill-nearing-market" rel="nofollow" target="_blank">http://israel21c.org/headlines/groundbreaking-insulin-pill-nearing-market</a> </strong>seeks to change Type 2 diabetes treatment from a daily injection to a daily pill. Its oral insulin capsule recently received patent approval in the EU, and is in Phase 2 clinical trials under an Investigational New Drug application with the FDA. Jerusalem-based Oramed is also moving forward with clinical trials of a capsule to treat Type </span><span lang="EN-AU"><br><br><strong>6. Premia Spine <a title="http://israel21c.org/health/new-implant-is-alternative-to-spinal-fusion" href="http://israel21c.org/health/new-implant-is-alternative-to-spinal-fusion" rel="nofollow" target="_blank">http://israel21c.org/health/new-implant-is-alternative-to-spinal-fusion</a> </strong>developed the TOPS (Total Posterior Solution) System, aiming to revolutionize the spinal implant market with an artificial joint in the same way that total hip and total knee replacement systems made hip and knee fusions a thing of the past. TOPS is available already in Austria, Germany, the UK, Turkey and Israel. An FDA study is now in the follow-up </span><span lang="EN-AU"><br><br><strong>7. Mapi Pharma <a title="http://israel21c.org/headlines/mapi-pharma-patents-new-ms-pain-relief-drugs" href="http://israel21c.org/headlines/mapi-pharma-patents-new-ms-pain-relief-drugs" rel="nofollow" target="_blank">http://israel21c.org/headlines/mapi-pharma-patents-new-ms-pain-relief-drugs</a> </strong>recently won US patents for two promising slow-release platforms for drugs to treat multiple sclerosis symptoms and pain. “We believe in two to three years they could be in the final stage of development, and about three years to market,” says Mapi Pharma president and CEO Ehud Marom. Another slow-release platform for a schizophrenia drug is next in the pipeline.<br><br><strong>8. Discover Medical </strong>introduced the SomnuSeal mask http://<a title="http://israel21c.org/health/new-device-for-sleep-apnea-is-easier-on-the-heart/" href="http://israel21c.org/health/new-device-for-sleep-apnea-is-easier-on-the-heart/" rel="nofollow" target="_blank">israel21c.org/health/new-device-for-sleep-apnea-is-easier-on-the-heart/</a>for CPAP machines – used widely by sufferers of Sleep-Apnea – in Europe. If sales are successful, the US market will be next. Because SomnuSeal is more comfortable than the current masks used with the machine, compliance could be much greater. Plus, the device does not put strain on the heart as the current mask does.<br></span><span lang="EN-AU"><br><br><br><strong>9. Real Imaging</strong> is in the midst of European clinical trials of RUTH<a title="http://israel21c.org/health/a-game-changer-in-breast-cancer-detection" href="http://israel21c.org/health/a-game-changer-in-breast-cancer-detection" rel="nofollow" target="_blank">http://israel21c.org/health/a-game-changer-in-breast-cancer-detection</a>, its radiation-free, contact-free, inexpensive and advanced imaging system for early detection of breast cancer.<strong> </strong>The system, which has won patent approvals in several countries, analyzes 3D and infra-red signals emitted from cancerous and benign tissue, generating an objective report that needs no interpretation. Founder and CTO Boaz Arnon presented RUTH at the most recent conference of the Radiological Society of North America. Initial release of the product will likely be in Europe sometime in 2015.<br></span><span lang="EN-AU"><br>RUTH, a hands-off breast cancer detection alternative.<br><br><strong>10. NeuroQuest <a title="http://israel21c.org/health/blood-test-for-alzheimers" href="http://israel21c.org/health/blood-test-for-alzheimers" rel="nofollow" target="_blank">http://israel21c.org/health/blood-test-for-alzheimers</a></strong> has started clinical testing in the United States, under the auspices of Harvard Clinical Research Institute, for its ground-breaking blood test to detect early-stage Alzheimer’s disease. Initial trials in Israel showed NeuroQuest’s test – based on research by Prof. Michal Schwartz of the Weizmann Institute of Science – to be 87 % accurate with an 85% specificity rate in detecting Alzheimer’s and ALS, two common neurodegenerative diseases. <br><br><br><strong>Related Articles<br></strong> <br><strong>About Abigail Klein Leichman<br></strong>Abigail Klein Leichman is a writer and associate editor at ISRAEL21c. Prior to moving to Israel in 2007, she was a specialty writer and copy editor at a daily newspaper in New Jersey and has free-lanced for a variety of newspapers and periodicals</span></span></p><p><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"> </span></p></div><div style="margin-bottom: 12pt;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"> </span></div><p><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"> </span></p></div><div><br></div></div><span class="HOEnZb" style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"> </span></div><span class="HOEnZb" style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><u></u><u></u></span></div><span class="HOEnZb" style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"></span></div><span class="HOEnZb" style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"></span></div><span class="HOEnZb" style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"></span></div><span class="HOEnZb" style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br><br clear="all"><br>-- <br><div><img src="https://mail.google.com/a/carolinaoneplus.com/photos/static/AD34hIgWiLOFiEL5v4I8luMpKfVnb0y2hka82PIWnUhqG3wFNvs7bxkHFgI5CfOeV-KyVOyjyAHzSiCJQL3FUBLoX64b54QvrEnwW0RDKozhg40XoccycAs"><br>Larry Pierson<br>Cell - <a href="tel:843-478-8778" value="+18434788778" target="_blank">843-478-8778</a><br>Work Office - <a href="tel:843-886-8110" value="+18438868110" target="_blank">843-886-8110</a><br><a href="http://www.larrypierson.com/" target="_blank">www.larrypierson.com</a><br><a href="mailto:lpierson@carolinaone.com" target="_blank">lpierson@carolinaone.com</a></div></span></div></div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br><br clear="all"></span><div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br></span></div><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">-- <br></span><div dir="ltr"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Bill Temple<br>19 Linkside Ct.<br>Isle of <a href="x-apple-data-detectors://28/0" x-apple-data-detectors="true" x-apple-data-detectors-type="address" x-apple-data-detectors-result="28/0">Palms, SC 29451</a><br><a href="tel:843-364-8574" x-apple-data-detectors="true" x-apple-data-detectors-type="telephone" x-apple-data-detectors-result="28/1">843-364-8574</a>(C)</span></div><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-12934765442107765252014-06-10T14:09:00.001-05:002014-06-10T14:09:07.461-05:006 reasons why the market for biosensor wearables is changing
<p> <span class="updated" title="2014-06-10T06:30:22Z" style="-webkit-text-size-adjust: auto; line-height: 1.3em;"><time datetime="2014-06-10T06:30:22+00:00" itemprop="datePublished">June 10, 2014</time> 6:30 am</span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;"> </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;">by</span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;"> </span><span class="fn" style="-webkit-text-size-adjust: auto; line-height: 1.3em;"><span itemprop="author" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name"><a href="http://medcitynews.com/author/sbaum/" title="Posts by Stephanie Baum" rel="author" style="text-decoration: none;">Stephanie Baum</a></span></span></span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;"> </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;">| 0 Comments</span></p>
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<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">A new report from <a href="http://rockhealth.com/" style="text-decoration: none;">Rock Health</a> looking at the future of the biosensor wearables market shows a market in transition. The next generation of wearables is more targeted towards patient populations, particularly chronic conditions. <a href="https://plus.google.com/u/0/events/ca501uqpql4eeorp5f7rdtg0k18" style="text-decoration: none;">In a Google hangout about the report</a>, Malay Gandhi, a co-author of the report, talked about some of the qualities that are making these wearables more appealing to consumers and the b2b market and features that will give them staying power.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><strong>Athletic trackers aimed at the mass market have lost ground</strong> <a href="http://medcitynews.com/2014/04/fuelband-dead-mean-wearables-healthcare/" style="text-decoration: none;">Nike’s exit from the wearables market</a> shows there are far more fitness tracking devices than the market can support. There’s also a certain amount of consumer fatigue because the accuracy of fitness bands can vary. It’s difficult to keep most consumers interested in using them after six months. That prompted <a href="http://bits.blogs.nytimes.com/2014/04/27/for-fitness-bands-slick-marketing-but-suspect-results/?_php=true&_type=blogs&_r=0" style="text-decoration: none;">The New York Times article comparing these wristbands to "digital snake oil.</a>" Another problem is the marketing. Companies have pursued an aspirational market. Rather than focusing on specific-use cases, they have taken a generic, mass market approach with the expectation that consumers will get it and see their inherent value. The successful companies will the ones that can diversify and show how their wearables applies to specific needs. Commoditization has forced companies to develop more sophisticated tools.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><strong>The impact of smartphones, ACA </strong>Smartphones have catalyzed the market for biosensor wearables. Wearables can offload the display through software apps, computing and Internet connectivity to a smartphone. Bluetooth has made the transfer of data between devices and smartphones energy efficient. The Affordable Care Act has spurred the pursuit of value-based care. Insurers and employer wellness plans see in these wearables the potential for an objective source of truth to reward incentives for reaching wellness objectives, or how the member is falling short.</span></p>
<p style="margin-bottom: 10.5px;"><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;"><br>The report also highlights three specific areas in which biosensor wearables need to evolve. Companies will need to focus on clinical endpoints and will have to be more committed to their technology passing clinical muster if their products are to be taken seriously by the medical and scientific community.</span><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><strong>Big players</strong> <strong>could mean less fragmentation</strong> The reluctance by wearable companies to align themselves with one network has led to more fragmentation. But with the entrance of Samsung and Apple into the wearables market as well as Google’s contact lens for non-invasive glucose monitoring in January this year show that this could change in the near future.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><strong>Functionality</strong> This is what determines the wearable’s potential usefulness to users. Gandhi’s example of <a href="http://www.lumobodytech.com/lumoback/" style="text-decoration: none;">Lumoback</a> — a posture improvement tool — gives feedback on posture and instructs users on what they need to do to improve it. That’s something that a heart rate tracker cannot do as effectively.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><strong>Reliability</strong> The need for valid data for clinical decisions requires the ability to consistently generate accurate data. FDA clearance is critical to building b2b customers across physician practices and hospitals that many biosensing wearable companies are chasing. A good example of a biosensor wearable company that’s meeting this demand is the maker of the <a href="http://www.proteus.com/todays-products/introducing-helius/" style="text-decoration: none;">swallowable pill tracker Helius by Proteus</a>.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><strong>Convenience</strong> goes hand in hand with engagement. Without convenience, companies lose engagement, or as Gandhi put it, "it falls right off a cliff." It’s also one of the toughest things to get right. Packaging and insights on the user experience are critical to making it work. Gandhi pointed to <a href="http://www.nspirehealth.com/" style="text-decoration: none;">Spire</a>, a tool that tracks respiration. It can be used for COPD or asthma and other respiratory illnesses. It can be worn in several different places and supports wireless charging.</span></p>
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<span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br><br> mo<a href="http://medcitynews.com/2014/06/5-ways-market-wearables-healthcare-changing/#ixzz34GU016us" style="text-decoration: none;">http://medcitynews.com/2014/06/5-ways-market-wearables-healthcare-changing/#ixzz34GU016us</a></span>
<div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-18646142457878356742014-06-08T18:46:00.001-05:002014-06-08T18:46:40.347-05:00Artificial Intelligence Raises New Hope for Cancer Patients
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<p class="date" style="box-sizing: border-box; margin-bottom: 0px; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">June 7, 2014, 6:28 AM PDT</span></p>
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<p class="author" style="box-sizing: border-box; margin-bottom: 2px; font-weight: 600; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">By James Temple</span></p>
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<ul class="inline-list" style="box-sizing: border-box; margin-bottom: 0px; padding-left: 0px; list-style-type: none;"><li style="box-sizing: border-box; margin-right: 0.3125rem; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; list-style: none; float: left; display: block;"><a href="http://twitter.com/jtemple" class="twitter" title="James Temple on Twitter" style="box-sizing: border-box; text-decoration: none; display: block; background-position: -32px -58px;"><span class="fa-stack fa" style="box-sizing: border-box; display: inline-block; -webkit-font-smoothing: antialiased; position: relative; width: 2em; height: 2em; vertical-align: middle;"><font color="#000000"><span class="fa fa-circle fa-stack-2x" style="box-sizing: border-box; display: inline-block; -webkit-font-smoothing: antialiased; position: absolute; left: 0px; width: 32px; text-align: center; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"></span></font></span></a></li></ul>
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<div class="row" style="box-sizing: border-box; margin-right: 320px; margin-left: -0.625rem; width: auto; max-width: none;"><div class="large-12 columns" style="box-sizing: border-box; padding-right: 0.625rem; padding-left: 0.625rem; position: relative; width: 660px; float: left;"><div class="sharedaddy sd-sharing-enabled" style="box-sizing: border-box; clear: both; border: none !important;"><div class="robots-nocontent sd-block sd-social sd-social-icon sd-sharing" style="box-sizing: border-box; border: none !important;"><div class="sd-content" style="box-sizing: border-box;"><ul style="box-sizing: border-box; float: right; margin-bottom: 0.7em !important; padding-left: 0px !important; list-style-type: none !important;"><li class="share-linkedin" style="box-sizing: border-box; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; display: block; list-style: none; float: left;"><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;">On Monday mornings, Bob Michaels walks into the infusion center at Weill Cornell Medical College in New York City and takes a seat in a comfortable barcalounger.</span></li></ul></div></div></div></div></div>
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<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">An oncology nurse connects the port implanted in the retired university professor’s chest to a portable IV pump. The device will deliver a continuous supply of an experimental therapy over the next four days, as he carries it around in a small shoulder bag.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><a href="https://recodetech.files.wordpress.com/2014/06/decode-copy.png" style="box-sizing: border-box; text-decoration: none; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font color="#000000"><img class="alignleft size-medium wp-image-53796" src="http://recodetech.files.wordpress.com/2014/06/decode-copy.png?w=760&h=300" alt="" width="380" height="150" originalw="380" originalh="150" src-orig="http://recodetech.files.wordpress.com/2014/06/decode-copy.png?w=380&h=150" scale="2" style="box-sizing: border-box; border-style: none; max-width: 100%; height: auto; display: inline-block; vertical-align: middle; margin-top: 5px; margin-right: 20px; margin-bottom: 20px;"></font></a></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Doctors diagnosed Michaels, 70, with bladder cancer in the late summer of 2011 (we’ve changed his last name for medical privacy reasons). Despite several rounds of surgery and chemotherapy, the cancer continued to metastasize. His doctors were running out of treatment options.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Which is what brings Michaels to that barcalounger. Weill Cornell is one of several facilities participating in a clinical trial for the promising cancer drug, known as BPM 31510.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The study itself is largely indistinguishable from the hundreds of cancer trials under way at any given time in the United States — but the drug development process was unorthodox. It wasn’t a scientist who spotted the potential of BPM 31510. It was an artificial intelligence program, running on the servers of a Framingham, Mass., startup named Berg Pharma.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">It’s among a growing number of companies and researchers applying smart algorithms and massive amounts of data to sift through gigantic stacks of medical research or the biology of the body itself for clues that could save the lives of cancer patients.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The techniques in question cross the fuzzy boundaries of AI, machine learning, computational medicine, quantitative pharmacology and plain old big data (and any practitioner will happily argue at length about which is what and why their approach is superior). But institutions as big as IBM, <a href="http://www.nytimes.com/2012/11/24/science/scientists-see-advances-in-deep-learning-a-part-of-artificial-intelligence.html" style="box-sizing: border-box; text-decoration: none;">Merck</a>, Memorial Sloan Kettering, UC Berkeley and the U.S. Food and Drug Administration are eager to explore the potential — and in most cases are investing millions to do so.</span></p>
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<span class="conference-banner banner-quote" style="box-sizing: border-box; position: absolute; display: block; width: auto; height: 30px; padding-right: 10px; top: 20px; left: 0px; z-index: 5; background-image: url(http://s1.wp.com/wp-content/themes/vip/recode/img/_events/dots-red.png); background-size: 100%; background-repeat: no-repeat repeat;"><span class="banner-title" style="box-sizing: border-box; display: block; font-weight: bold; padding: 6px 0px 0px 14px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">QUOTED:</span></span><span class="banner-fold" style="box-sizing: border-box; position: absolute; top: 30px;"></span></span><blockquote><p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"My real hope, the deep hope, is that this is a home run."</span></p></blockquote>
<p class="attribution" style="text-indent: 0px; box-sizing: border-box; margin-bottom: 1.25rem; padding-right: 55px; padding-left: 55px; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Bob Michaels, cancer patient participating in the Berg Pharma clinical trial</span></p>
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<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The research efforts roughly break down into two tracks: Those using these computational tools to improve personalized medicine, pinpointing the most effective existing drugs against an individual’s specific cancerous mutations — and those, like Berg, attempting to develop brand new treatments.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Therapies such as BPM 31510 will ultimately have to pass the same hurdles as any drug candidate. But the company hopes the approach vastly accelerates drug discovery and dramatically reduces the cost. The average price of developing a successful treatment easily surpasses $1 billion — but can exceed $4 billion when failed drug candidates are taken into account, as <a href="http://www.forbes.com/sites/matthewherper/2012/02/10/the-truly-staggering-cost-of-inventing-new-drugs/" style="box-sizing: border-box; text-decoration: none;">Forbes has noted</a>.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"We think we’ll cut the drug development time at least in half and cut costs at least by 50 percent or more," said Niven Narain, chief technology officer at Berg. "Our goals are to really make a tremendous impact on changing the American health care system."</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Michaels’ goal is more immediate and personal.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"My real hope, the deep hope, is that this is a home run," he said. "That it wipes out the metastatic cancer and I live another thirty years like a healthy person."</span></p>
<h3 class="red" style="box-sizing: border-box; margin-top: 0.2rem; margin-bottom: 0.5rem; padding-bottom: 0px; font-weight: 500; text-rendering: optimizelegibility; visibility: visible;"><font size="4"><span style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Grist For The Mill</span></font></h3>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">There are plenty of reasons to keep expectations in check for any single drug candidate — or the computational approach in general. <a href="http://directorsblog.nih.gov/2013/06/18/crowdsourcing-therapeutic-molecules-for-drug-discovery/" style="box-sizing: border-box; text-decoration: none;">More than 95 percent of drug candidates fail</a> in clinical trials and there’s a long history of premature claims in medicine, particularly when it comes to cancer.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"> </p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"This is certainly promising, but it doesn’t mean we’ll be successful," said David Patterson, a professor of computer science at UC Berkeley developing machine learning tools for cancer research. "Many people have gotten excited about new technologies many times in cancer."</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">But he and other observers strongly suspect that digitizing biology will ultimately represent a fundamental step forward. A convergence of forces may have finally put medicine onto the trajectory of Moore’s Law, promising accelerating advances in understanding and treatments, including: the plummeting cost of DNA sequencing, the accelerating power of computational tools, improving understanding of the genomic basis of cancers and growing mounds of medical data.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In a strong signal of the perceived promise of these approaches, the FDA last month announced funding for the UCSF-Stanford Center of Excellence in Regulatory Science and Innovation, a joint effort designed to leverage diverse data sets and computational tools to accelerate drug development.</span></p>
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<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"We’re seeing this ‘big data’ trend in everything, but at least in this area it’s very exciting," said Michael Keiser, an instructor at the UC San Francisco School of Medicine and founder of <a href="https://www.seachangepharma.com/" style="box-sizing: border-box; text-decoration: none;">SeaChange Pharmaceuticals</a>. "The traditional problem was just not having the grist for the mill."</span></p>
<h3 class="red" style="box-sizing: border-box; margin-top: 0.2rem; margin-bottom: 0.5rem; padding-bottom: 0px; font-weight: 500; text-rendering: optimizelegibility; visibility: visible;"><font size="4"><span style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">My Dear Watson</span></font></h3>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Glioblastoma multiforme is an <a href="https://www.aans.org/Patient%20Information/Conditions%20and%20Treatments/Glioblastoma%20Multiforme.aspx" style="box-sizing: border-box; text-decoration: none;">aggressive brain cancer</a> that, by some estimates, kills more than 13,000 people in the United States each year (including, in 2008, <a href="http://www.sfgate.com/magazine/article/Father-s-death-spurs-son-to-reach-new-heights-2480194.php#page-1" style="box-sizing: border-box; text-decoration: none;">my father</a>).</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The existing standard of care is a combination of "debulking" surgery, radiation and chemotherapy. It can add months to a patient’s life, but typically the cancer makes a swift return.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In March, IBM announced a clinical study in partnership with the New York Genome Center aimed at improving the odds by using the tech giant’s Watson artificial intelligence system to hit upon more personalized treatment plans.</span></p>
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<span class="conference-banner banner-quote" style="box-sizing: border-box; position: absolute; display: block; width: auto; height: 30px; padding-right: 10px; top: 20px; left: 0px; z-index: 5; background-image: url(http://s1.wp.com/wp-content/themes/vip/recode/img/_events/dots-red.png); background-size: 100%; background-repeat: no-repeat repeat;"><span class="banner-title" style="box-sizing: border-box; display: block; font-weight: bold; padding: 6px 0px 0px 14px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">QUOTED:</span></span><span class="banner-fold" style="box-sizing: border-box; position: absolute; top: 30px;"></span></span><blockquote><p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"You’re really trying to find the needle in the haystack."</span></p></blockquote>
<p class="attribution" style="text-indent: 0px; box-sizing: border-box; margin-bottom: 1.25rem; padding-right: 55px; padding-left: 55px; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Steve Harvey, global technology and analytics leader at IBM</span></p>
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<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Cancers are often classified into location types – lung, breast, cervical — that suggest they’re homogenous. But tumors are unpredictable bundles of mutations, as many as a million among the three billion nucleotide base pairs in the human genome. And different mutations respond in different ways to different treatments.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">For the approximately 25 patients in the study, the genome center will conduct whole DNA sequencing of normal cells and tumor cells to ascertain the precise mutations at work.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">What typically happens at this point is technicians will tediously scan for known mutations and match them to drugs with demonstrated success in treating them. But the vast number of possible mutations and endless cancer studies add up to a big data problem that’s outstripping the capacities of human minds.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"You’re really trying to find the needle in the haystack," said Steve Harvey, global technology and analytics leader at IBM.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Enter Watson, which can gobble up entire databases of medical literature and easily handle terabytes of genomic data, drawing lines between mutations and treatments that might have been missed before. The system can literally cut down the process from weeks to minutes, while covering a broader swath of the scientific literature.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><font color="#000000"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Glioblastoma patients are in a race against time. Most will die within 15 months and many will pass away much sooner — so cutting down the amount of time it takes to identify treatments is critical in itself.</span></font></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Many drug candidates are abandoned if they didn’t directly attack the principal target of a particular study, even if they were shown to be effective against some other mutations. But any drug candidate that made it through a Stage 1 clinical trial could potentially be used for patients in the current study.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">IBM and the New York Genome Center are in the early stages of developing the study, which will begin later this year. Separately, oncologists at the Memorial Sloan-Kettering Cancer Center are collaborating with IBM to develop a Watson application that could help doctors identify treatments for patients with lung cancer.</span></p>
<h3 class="red" style="box-sizing: border-box; margin-top: 0.2rem; margin-bottom: 0.5rem; padding-bottom: 0px; font-weight: 500; text-rendering: optimizelegibility; visibility: visible;"><font size="4"><span style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">A New Frontier</span></font></h3>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">But others say that identifying the best known treatments isn’t the real problem – it’s finding novel ones.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"It’s not that the answer is in the literature," UC Berkeley’s Patterson said. "We need to do new experiments to find things that haven’t been tried before."</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">His team is collaborating with Dr. Brian Druker at Oregon Health and Science University on a study of <a href="http://www.cancer.gov/cancertopics/pdq/treatment/adultAML/healthprofessional/page1" style="box-sizing: border-box; text-decoration: none;">acute myeloid leukemia</a>, a deadly form of blood cancer.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">A growing number of scientists believe the most effective treatments against certain cancers will not be a single silver bullet — but a cocktail of treatments, much as with HIV.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">For Druker’s study, which is just getting under way, the researchers will sequence numerous patient blood samples. Then they’ll feed that information plus clinical data about various compounds into the machine learning algorithms at UC Berkeley, hoping to spot a handful of drugs likely to help.</span></p>
<p class="snippet-left" style="box-sizing: border-box; margin-right: 15px; margin-bottom: 15px; width: 320px; float: left;"></p>
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<a class="title" href="http://recode.net/2014/04/23/uw-scientist-designs-life-from-scratch/" style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em; box-sizing: border-box; text-decoration: none; border-bottom-width: 1px; border-bottom-style: dotted; border-bottom-color: rgb(0, 0, 0);"> </a><br>
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<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In turn, they plan to rapidly test different combinations in varying proportions against the blood samples in Druker’s laboratory.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">That data will flow back into the software. It promises to create a positive feedback loop that makes the algorithms increasingly smarter, more adept at finding the customized combination that will be most effective for any given person.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In a sense, the study straddles the two major approaches mentioned at the start: Taking known treatments but applying them in a novel way.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"We’re going from a biologically-intensive field to a more computer science-intensive field," Patterson said. "There’s been a million-fold improvement in the cost of sequencing. It’s turning that information into bits — and that’s why we can step in."</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"Computer scientists can deal with terabytes or petabytes of information," he said. "That’s in our wheelhouse."</span></p>
<h3 class="red" style="box-sizing: border-box; margin-top: 0.2rem; margin-bottom: 0.5rem; padding-bottom: 0px; font-weight: 500; text-rendering: optimizelegibility; visibility: visible;"><font size="4"><span style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">A terrible case</span></font></h3>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Michaels felt rundown throughout the summer of 2011, uncomfortable in his own body. But he was determined to enjoy the season and put off the inevitable round of doctors visits until fall. Then before dawn one morning, he woke up and rushed to the bathroom.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"It came out like burgundy wine," he said.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">After the initial biopsy, Michaels’ doctors decided to attack what they believed was a contained tumor with a six-week course of Bacillus Calmette-Guerin, a vaccine that stimulates the immune system. It was delivered through a urinary catheter, which was "no fun," he said.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Worse, it didn’t work. They next performed a radical cystectomy, the removal of the bladder, at which point his urologist discovered the cancer was more widespread than originally thought.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Michaels underwent a round of chemotherapy — and another and another. The treatments alleviated symptoms, but the cancer continued to metastasize, most recently surfacing in the omentum, part of the lining of the abdominal cavity.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Dr. Scott Tagawa, Michaels’ oncologist at Weill Cornell, finally counseled him to consider the Berg Pharma clinical trial.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"He’s a very straight shooter, who was willing to say, ‘this is a really terrible case and (BPM 31510) looks pretty good,’" Michaels said. "I decided to go for it."</span></p>
<h3 class="red" style="box-sizing: border-box; margin-top: 0.2rem; margin-bottom: 0.5rem; padding-bottom: 0px; font-weight: 500; text-rendering: optimizelegibility; visibility: visible;"><font size="4"><span style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Deranged cells</span></font></h3>
<p></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Berg Pharma, cofounded in 2006 by <a href="http://www.forbes.com/profile/carl-berg/" style="box-sizing: border-box; text-decoration: none;">Silicon Valley real estate magnate Carl Berg</a>, is squarely in the camp of looking for new treatments.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">For any given condition, the company begins by running a broad array of tests on a large number of healthy and diseased samples. They analyze tissue, blood, urine and more to identify the constituent DNA, proteins, lipids, metabolites and more.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Then the company creates artificial intelligence computer models that compare the two, ideally highlighting what has gone wrong in the diseased cells, what heightened level of proteins or missing lipids might be at work.</span></p>
<p></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">For cancer, Berg Pharma homed in on mitochondria, a structure within cells that influences a process known as apoptosis — or programmed cell death.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">It’s the mechanism that usually causes old or damaged cells to self-destruct.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"But cancer cells unfortunately have subverted this normal metabolic process," said Peter Yu, the oncologist overseeing the Berg trial at the Palo Alto Medical Center in Silicon Valley.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">This allows deranged cells to invade healthy tissue and often spread throughout the body, which is precisely why the disease is so deadly.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">BPM 31510 appears to switch mitochondria back on, restoring apoptosis – at least in the lab and in animals. That’s especially intriguing because it would seem to work across cancer types — no matter the genetic mutation — by addressing the underlying mechanism itself.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Altogether, nearly 40 patients are enrolled in the study, which spans Weill Cornell, Palo Alto Medical Foundation and the University of Texas MD Anderson Cancer Center.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"We’re one of the first companies, if not the first, to bring artificial intelligence into medicine for the purpose of developing drugs," Berg’s Narain said.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Ultimately, though, it doesn’t matter how novel the approach is, or whether it happens in academia or private industry. What matters is whether it leads to the identification or creation of treatments that save or extend lives.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">At this point, Yu said that nothing can be said scientifically about the effectiveness of the drug in humans. The current trial phase will continue through 2015, and the drug would still have several stages to go before the FDA could approve it.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Michaels is only a case study of one and he’s on chemotherapy as well. But he personally feels like the drug is working. He says his abdominal pain has subsided, his energy has improved and he’s working out again for the first time in more than a year.</span></p>
<p style="box-sizing: border-box; margin-bottom: 1.25rem; text-rendering: optimizelegibility;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"It’s really extraordinary," he said. "I feel it’s like mentioning a no-hitter in the ninth inning, I don’t want to jinx it. But I’m hoping it’s going to do the job."</span></p>
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<div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-28454590277074321012014-05-25T14:28:00.001-05:002014-05-25T14:28:52.472-05:00Vinod Khosla is back with some more predictions about the future of healthcare
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<span class="updated" title="2014-05-20T14:25:04Z" style="-webkit-text-size-adjust: auto; font-size: 18px; line-height: 1.3em;">May 20, 2014 2:25 pm</span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; font-size: 18px; line-height: 1.3em;"> </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; font-size: 18px; line-height: 1.3em;">by</span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; font-size: 18px; line-height: 1.3em;"> </span><span class="fn" style="-webkit-text-size-adjust: auto; font-size: 18px; line-height: 1.3em;"><a href="http://medcitynews.com/author/gregory-ferenstein/" title="Posts by Gregory Ferenstein" rel="author" style="text-decoration: none;">Gregory Ferenstein</a></span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; font-size: 18px; line-height: 1.3em;"> </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; font-size: 18px; line-height: 1.3em;">| 1 Comments</span><br>
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<img src="http://medcitynews.com/wp-content/uploads/5036850181_8220322589-300x199.jpg" alt="VC says machines can replace 80% of what docs do" width="300" height="199" class="alignright size-medium wp-image-150085" style="max-width: 100%; vertical-align: middle; display: inline; margin-left: 1.625em;"><p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Vinod Khosla, <a href="http://venturebeat.com/2013/09/11/vinod-khosla-vcs-should-hush-up-because-they-havent-done-sht/" style="text-decoration: none;">sassy</a> VC and legendary co-founder of Sun Microsystems, has predicted the future of health.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In essence, he has said, our medical lives will become <a href="http://venturebeat.com/2012/09/02/vinod-khosla-says-technology-will-replace-80-percent-of-doctors-sparks-indignation/" style="text-decoration: none;">increasingly automated</a>, with ultra-intelligent systems prescribing fine-grain recommendations to nurse us back to health. According to a newly released report, he predicts:</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">1. 80 percent of what doctors do, diagnostics, will be replaced by machines<br>2. Medicine will become tailor-made for each patient<br>3. Consumer-driven tech will create better incentives to keep people healthy</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">For good measure, we think Khosla missed one important aspect of the future: we’ll move from disease care to actual <em>health</em> care. That is, thanks to pervasive monitoring, our goals won’t simply be to not be sick but to become the best person we can be.</span></p>
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<span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; font-size: 18px; line-height: 1.3em;">"In the past, the data to make more rigorous and scientific conclusions has simply not been available," reads Khosla’s most recent draft report [</span><a href="http://www.khoslaventures.com/wp-content/uploads/20-Percent-Doctor-Included_DRAFT.pdf" style="-webkit-text-size-adjust: auto; font-size: 18px; line-height: 1.3em; text-decoration: none;">PDF</a><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; font-size: 18px; line-height: 1.3em;">].</span><strong style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font size="4">A fidelity to science</font></strong>
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<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"And as a result, medical literature is rife with studies about how the practice of medicine does not meet expectations for what would constitute sufficient, correct care."</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In one case, he notes, a major meta-analysis contradicted advice on the use of beta-blockers to prevent those at risk of stroke. "Despite being discredited, the AHA guideline has not been retracted as of 2013," he concludes. The sheer volume of information is difficult to keep up with, even for the smartest doctors.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Smart diagnostic robots will able to apply the most advanced science to common problems. "That’s not to say 80 percent of doctors will go away. It’s that systems and consumers (directly) will handle 80 percent of their current work, so the role of the doctor will adapt dramatically to add value."</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In this case, think about IBM’s Jeopardy champion, Watson, which is already showing signs that it can <a href="http://venturebeat.com/2013/10/18/ibm-watson-fires-its-own-cancer-fighting-moonshot/" style="text-decoration: none;">diagnose cancer</a> better than some doctors.</span></p>
<h2 style="font-weight: normal; text-rendering: optimizelegibility;"><strong style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font size="4">Tailor-made for you</font></strong></h2>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Advanced manufacturing will combine with big data to make tailor-made recommendations and drug prescriptions.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"Data science will start to tell us how to measure the effectiveness of a particular drug for a particular patient’s specific conditions/genomics, environment/ethnicity, as opposed to the status quo of having drug companies develop one drug for all seven billion people on the planet," Khosla predicts.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Doctors are already using genomic sequencing <a href="http://america.aljazeera.com/articles/2013/12/2/using-the-human-genometocustomtailormedicineforpatients.html" style="text-decoration: none;">to target</a> treatment more precisely. And chemists have tested existing 3D printers to replicate drugs. So, instead of all patients taking the same pill, measured out in oddly convenient integers, a home printer will delivery print a drug has precisely the amount of medicine you need.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Check out this TED talk on the subject:</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Still, Khosla may have overlooked the controversial key needed to unlock this precision: public health data. In order to use all available health data collected, we have to combine health datasets. But combining that information has recently been <a href="http://techcrunch.com/2014/03/19/larry-pages-wish-to-make-all-health-data-public-has-big-benefits-and-big-risks/" style="text-decoration: none;">used to re-identify</a> anonymized data.</span></p>
<h2 style="font-weight: normal; text-rendering: optimizelegibility;"><strong style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font size="4">Consumer tech & better incentives</font></strong></h2>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">It is true that the Affordable Care Act ("Obamacare") <a href="http://blogs.hbr.org/2013/09/value-based-health-care-is-inevitable-and-thats-good/" style="text-decoration: none;">attempts</a> to reward doctors for the outcomes of their patients, but that isn’t the case with the entire medical innovation industry.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Diagnostic devices are getting cheaper and cheaper; entrepreneurs may have different incentives to build tools that are both cheaper and more accurate, unlike hospitals.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"Medical device manufacturers, like those that build and sell huge scanning systems, don’t want to cannibalize sales of their expensive equipment by providing cheaper, more accessible monitoring devices, such as a $29 ECG monitor," reads the report.</span></p>
<p style="margin-bottom: 10.5px;"><a href="http://venturebeat.files.wordpress.com/2014/05/s4_front.png" style="text-decoration: none; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font color="#000000"><br><br></font></a></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Once expensive electrocardiograms can now fit on the back of an iPhone, Khosla continues, "Health insurance could give people similar financial rewards for improving their health and further making the consumer the CEO of his own health."</span></p>
<h2 style="font-weight: normal; text-rendering: optimizelegibility;"><strong style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font size="4">Optimal health</font></strong></h2>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Khosla’s otherwise fascinating look at the future of health has one important oversight: The overarching theme is still curing diseases, not optimizing health. The current health system assumes that as long as we’re not sick, there’s no reason to see a doctor.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">But consumer devices are showing how improvements in meditation, nutrition, and exercise can make us each better versions of ourselves.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Computer-guided meditation headsets <a href="http://www.thedailybeast.com/articles/2014/04/14/high-tech-meditation-swap-your-yogi-for-a-headset.html" style="text-decoration: none;">can already</a> help novice yogis learn the amazing benefits of mindfulness. The upcoming <a href="https://www.indiegogo.com/projects/muse-the-brain-sensing-headband-that-lets-you-control-things-with-your-mind" style="text-decoration: none;">Muse headband</a> will be able to read our brain waves throughout the day. This available technology will soon able to show us how our eating and sleeping habits influence our stress and focus all day long.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The Jawbone Up, once a simple pedometer, now has an app to measure how caffeine intake affects our sleep. Very soon, we’ll be immersed in technology that can show us in real time how to feel as refreshed and energetic as we can possibly be. Once people get a taste, they’ll want even more.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Moreover, ocular wearables like Google Glass will be able to <a href="https://gigaom.com/2014/04/03/dont-eat-that-sri-built-a-calorie-counting-food-app-that-works-via-a-photo-snap/" style="text-decoration: none;">automatically analyze</a> the nutritional content of food from a picture and then correlate that to weight gain measured by Internet-connected scales. We’ll know immediately what foods leave us drifting towards heart failure or vitamin deficiencies or closer to wellness and whole-body health.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Hybrid medical/sports startups, <a href="http://venturebeat.com/2011/09/26/founder-webmds-consumer-health-wellnessfx/" style="text-decoration: none;">such as blood-diagnostics company</a> WellnessFX, are beginning to cater to consumers who treat optimal living as their personal medical strategy. <a href="http://readwrite.com/2014/02/13/genetrainer-fitness-genomics#awesm=~oEMFBd5chvSAZV" style="text-decoration: none;">Genetrainer</a>connects to genetics testing startup 23andMe and tells budding athletes how to optimize their regiment for their particular genes.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Optimal health, with any luck, will increasingly be part of the medical industry.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">You can read Khosla’s very thorough forecast in this <a href="http://www.khoslaventures.com/wp-content/uploads/20-Percent-Doctor-Included_DRAFT.pdf" style="text-decoration: none;">PDF</a>.</span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><img src="http://stats.wordpress.com/b.gif?host=venturebeat.com&blog=342986&post=1476862&subd=venturebeat&ref=&feed=1" alt="" border="0" width="1" height="1" style="max-width: 100%; vertical-align: middle;"></span></p>
<p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">This article originally appeared on <a href="http://venturebeat.com/2014/05/20/vinod-khosla-has-3-predictions-for-the-future-of-health-weve-got-1-more/" rel="canonical" style="text-decoration: none;">VentureBeat</a></span></p>
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<div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-76721193971522238402014-05-14T15:25:00.001-05:002014-05-14T15:25:33.730-05:00Breath test for cancer detection and other conditions could offer less invasive diagnostic<p> <span class="updated" title="2014-05-13T17:25:03Z" style="-webkit-text-size-adjust: auto; line-height: 1.3em;">May 13, 2014 5:25 pm</span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;"> </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;">by</span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;"> </span><span class="fn" style="-webkit-text-size-adjust: auto; line-height: 1.3em;"><a href="http://medcitynews.com/author/sbaum/" title="Posts by Stephanie Baum" rel="author" style="text-decoration: none;">Stephanie Baum</a> </span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;">| 0 Comments</span></p><p class="row" style="margin-left: -20px;"><div class="span8 share_box" style="float: left; margin-left: 20px; width: 620px; margin-bottom: 15px;"><div class="row" style="margin-left: -20px;"><div class="span4" style="float: left; margin-left: 20px; width: 300px;"><div class="inner" style="margin: 10px;"><div class="addthis_toolbox addthis_default_style addthis_32x32_style"><span class=" at300bs at15nc at15t_print" style="text-decoration: none; cursor: pointer; float: left; padding: 0px 2px; overflow: hidden; display: block; background-image: url(http://ct1.addthis.com/static/r07/widget060_32x32.gif) !important; height: 32px !important; width: 32px !important; background-position: 0px -6688px !important;"><span class="at_a11y" style="position: absolute !important; top: auto !important; width: 1px !important; height: 1px !important; overflow: hidden !important;"><span class=" at300bs at15nc at15t_compact" style="line-height: 1.3em; text-decoration: none; cursor: pointer; padding: 0px 2px; display: inline !important; overflow: hidden; margin-right: 4px; background-image: url(http://ct1.addthis.com/static/r07/widget060_32x32.gif) !important; height: 32px !important; width: 32px !important; background-position: 0px -5696px !important;"><span class="at_a11y" style="position: absolute !important; top: auto !important; width: 1px !important; height: 1px !important; overflow: hidden !important; display: inline !important;"><font color="#000000"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><a class="addthis_button_compact at300m" href="http://medcitynews.com/2014/05/breath-test-for-cancer-detection-and-other-conditions-could-offer-less-invasive-diagnostic/?utm_source=MedCity+News+Subscribers&utm_campaign=82d4ef3360-RSS_EMAIL_CAMPAIGN&utm_medium=email&utm_term=0_c05cce483a-82d4ef3360-67646345#" style="line-height: 1.3em; text-decoration: none; cursor: pointer; padding: 0px 2px; display: inline !important;">Sharing Servi</a></span></font><a class="addthis_button_expanded" target="_blank" title="View more services" href="http://medcitynews.com/2014/05/breath-test-for-cancer-detection-and-other-conditions-could-offer-less-invasive-diagnostic/?utm_source=MedCity+News+Subscribers&utm_campaign=82d4ef3360-RSS_EMAIL_CAMPAIGN&utm_medium=email&utm_term=0_c05cce483a-82d4ef3360-67646345#" style="-webkit-text-size-adjust: auto; font-weight: bold; line-height: 1.3em; border: 0px; background-image: none; height: 32px; margin: 0px; display: inline !important; text-decoration: none !important; width: 56px !important; padding: 0px !important;">33</a></span></span></span></span></p></div></div></div></div></div><div class="story-main-text entry-content"><div class="row" style="margin-left: -20px;"><div class="span8" style="float: left; margin-left: 20px; width: 620px;"><p style="margin-bottom: 10.5px;"><span style="line-height: 1.3em; background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto;">Car makers aren’t the only ones adapting breathalyzer technology to improve health and safety. A group of researchers from University of Vermont is developing a way to apply the technology</span><a href="http://www.smithsonianmag.com/science-nature/a-breathalyzer-test-for-bacterial-infections-1004887/?no-ist=" style="line-height: 1.3em; -webkit-text-size-adjust: auto; text-decoration: none;">to detect bacterial infections in the lungs, such as TB</a><span style="line-height: 1.3em; background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto;">. But researchers with Cleveland Clinic’s Respiratory Institute are working on a breath test for cancer detection,</span><span style="line-height: 1.3em; background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto;"> </span><a href="http://www.theatlantic.com/health/archive/2014/05/a-breathalyzer-that-can-diagnose-cancer/362102/" style="line-height: 1.3em; -webkit-text-size-adjust: auto; text-decoration: none;">according to a report in The Atlantic</a><span style="line-height: 1.3em; background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto;">.</span><br></p><p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Dr. Raed Dweik heads up the pulmonary vascular program at the institute. In an interview with The Atlantic he pointed out that breath tests are a discernable signature with what’s going on in the body just like the molecules from an air pocket contain molecules indicating the composition of the water they came from.</span></p><p style="margin-bottom: 10.5px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Among the conditions with distinct breath signatures are lung cancer, liver disease, heart disease, asthma and inflammatory bowel disease, according to Dweik. Even obesity carries a breath print, said Dweik. Not only would breathalyzer tests for these conditions be less invasive, they could be less costly than blood tests over the long term.</span></p><p style="margin-bottom: 10.5px;"><font color="#000000"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><a href="http://medcitynews.com/2013/10/breathalyzer-day-used-diagnose-disease/" style="text-decoration: none;">Diabetes is also an area of interest</a> for breath tests. Some researchers have found that acetone in the breath increases when the body is low on glucose.</span></font><iframe id="google_ads_iframe_/8312025/General_Story_Content_0" name="google_ads_iframe_/8312025/General_Story_Content_0" width="300" height="250" scrolling="no" marginwidth="0" marginheight="0" frameborder="0" style="-webkit-text-size-adjust: auto; line-height: 1.3em; border-width: 0px; vertical-align: bottom;"></iframe></p></div></div></div><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-73777768164680433282014-05-12T15:36:00.001-05:002014-05-12T15:36:14.633-05:00Your Computer Downtime Could Help Crack the Alzheimer’s Code<h1 style="margin-top: 0.2em; margin-bottom: 0.5em; padding-bottom: 0.4em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(221, 221, 221);"><br></h1><p nodeindex="133" style="margin-bottom: 1em; -webkit-hyphens: auto;"><cite style="margin: 0px 0px 25px; padding: 0px; position: relative; display: block;"><span class="ril_byline_content" style="margin: 0px; padding: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">by <a class="RIL_author" href="http://recode.net/people/dmitri-klimov/" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none; font-weight: bold;">Dmitri Klimov</a>, <a href="http://recode.net/" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">recode.net</a></span><span class="RIL_date" style="margin: 0px; padding: 0px; display: block; position: absolute; top: 0px; right: 0px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">May 11 12:00 PM</span></span></cite></p><p nodeindex="133" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br></span></p><p nodeindex="133" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Researchers at George Mason University have created a tool that allows anyone to donate their computer downtime to Alzheimer’s research, enlisting the public’s help in studying the sixth leading cause of death in the United States.</span></p><p nodeindex="134" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">A team led by Dmitri Klimov, an associate professor of computational biology in the School of Systems Biology, has constructed complex computer models to study molecules implicated in the disease.</span></p><p nodeindex="135" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">But the computer simulations can take months or even years with limited computing power, so the researchers collaborated with Paragon Computation on the Compute Against Alzheimer’s Disease project. The distributed computing platform allows thousands of computers to work together on the problem all at once. Anyone can install the software, which runs when their computer is idle, chipping into the scientific effort whenever it can. (Download it <a href="http://www.computeagainstalzheimers.org/" nodeindex="507" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">here</a>.)</span></p><p nodeindex="136" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">“Like a screensaver, it works only when you are not,” said Steven Armentrout, Paragon’s chief executive, in a statement.</span></p><p nodeindex="137" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">One of the main targets Klimov’s team is studying is the amyloid precursor protein. It’s normally innocuous, but it’s also the main component of the amyloid plaques that form in the brains of Alzheimer’s patients, for reasons little understood.</span></p><p nodeindex="138" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">“Despite all the efforts, we still don’t know how the disease develops on a molecular level,” Klimov said in a statement. “Exactly what causes Alzheimer’s is not known.”</span></p><p nodeindex="139" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Your favorite photo-sharing app or online game might have all the cloud computing power they need, often thanks to venture capital funds covering their Amazon Web Services bill. But despite the serious nature of the problems that academic researchers are working on, they too often have inadequate computing and monetary resources at their disposal.</span></p><p nodeindex="140" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Klimov earned a $300,000 grant from the National Institutes of Health to study the problem — a sizable pot for science, but a figure that wouldn’t even rate a <strong nodeindex="508" style="margin: 0px; padding: 0px;">Re/code</strong> story were it a venture capital round.</span></p><p nodeindex="141" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Distributed computing projects have become a common means of multiplying limited processing power. The Baker Laboratory at the University of Washington <a href="https://recode.net/2014/04/23/uw-scientist-designs-life-from-scratch/" nodeindex="509" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">created the Rosetta@Home tool</a> to help decipher or design proteins that could be used in therapeutics and vaccines against diseases like AIDS and influenza. (Download it <a href="http://boinc.bakerlab.org/" nodeindex="510" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">here</a>).</span></p><p nodeindex="142" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Going a totally different direction, researchers at UC Berkeley set up <a href="http://setiathome.ssl.berkeley.edu/" nodeindex="511" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">SETI@home</a>, leveraging distributed computing to analyze radio telescope data for signs of extraterrestrial intelligence.</span></p><p nodeindex="143" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Wikipedia <a href="https://en.wikipedia.org/wiki/List_of_distributed_computing_projects" nodeindex="512" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">lists dozens</a> of additional examples where researchers have asked the public to pitch in as citizen scientists.</span></p><p nodeindex="144" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">“It’s a way to involve people in real research,” Klimov said.</span></p><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-61873636884180317772014-04-18T01:06:00.001-05:002014-04-18T01:06:26.341-05:00Paraplegics Get Leg Function Back With Electrical Stimulation<p id="RIL_container" style="margin: 65px 145px;"><div id="RIL_header" style="padding-bottom: 1.5em;"><cite style="margin: 0px 0px 25px; padding: 0px; position: relative; display: block;"><span class="ril_byline_content" style="margin: 0px; padding: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">by <a class="RIL_author" href="mailto:j.gever@medpagetoday.com" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none; font-weight: bold;">John Gever</a>, <a href="http://medpagetoday.com/" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">medpagetoday.com</a></span><span class="RIL_date" style="margin: 0px; padding: 0px; display: block; position: absolute; top: 0px; right: 0px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">April 8</span></span></cite></p><p id="RIL_body" style="clear: both;"><div id="RIL_less"><div lang="en"><header nodeindex="274" style="margin: 0px; padding: 0px;"><div class="clinicalcontextinfo" nodeindex="281"></p><p class="byline" nodeindex="282"><div class="bylineleft" nodeindex="283"><div class="bylinepic" nodeindex="284"><br></p><p class="bylinetext" nodeindex="285"><div class="bylinename" nodeindex="286"><br></p></div></div></div><div class="articlecontrols" nodeindex="288"><div class="controlsright" nodeindex="295"></div></div></header><p nodeindex="310" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Three more patients with complete lower-body paralysis regained some ability to move their legs and feet voluntarily with electrical stimulation to their spinal cords, researchers said.</span></p><p nodeindex="311" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">After <a href="http://www.medpagetoday.com/Neurology/GeneralNeurology/26592" target="_blank" nodeindex="598" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">obtaining such results in one patient</a>, the subject of a <a href="http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60547-3/fulltext" target="_blank" nodeindex="599" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">2011 paper in <em nodeindex="600" style="margin: 0px; padding: 0px;">The Lancet</em></a>, a team based at the University of Louisville repeated the stimulation procedure in three more patients with even better success, they reported <a href="http://brain.oxfordjournals.org/content/early/2014/04/07/brain.awu038.full" target="_blank" nodeindex="601" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">online in</a><em nodeindex="602" style="margin: 0px; padding: 0px;">Brain</em>.</span></p><p nodeindex="312" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Whereas the first patient, then 25-year-old Rob Summers, required 7 months of stimulation before he showed any signs of voluntary movement in his lower extremities, the three subsequent patients were all moving their legs, feet, and/or toes within days of starting the treatment.</span></p><p nodeindex="313" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The intervention in all four patients consisted of a 16-electrode array implanted at vertebrae T11 and T12, over spinal cord segments L1 to S1, according to the report from <a href="http://louisville.edu/kscirc/bios/claudia-angeli-ph-d.html" target="_blank" nodeindex="603" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">Claudia Angeli, PhD</a>, and colleagues. Epidural stimulation was delivered at varying voltages with frequencies of 25 or 30 Hz.</span></p><p nodeindex="314" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In addition to the stimulation, patients underwent standing and stepping training with body weight support, in the clinic or at home, for more than a year in Summers' case and for up to 38 weeks in the newer patients.</span></p><p nodeindex="315" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">All four had been paralyzed for at least 2 years. Two retained some sensory function in their lower extremities but no motor ability; the other two had neither sensory nor motor function.</span></p><p nodeindex="316" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">With these new data, Angeli and colleagues have changed their minds about the likely reasons for the intervention's success.</span></p><p nodeindex="317" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Summers was one of those who still had feeling in his legs. In the 2011 <em nodeindex="604" style="margin: 0px; padding: 0px;">Lancet</em> report, the researchers speculated that the remaining sensory connections were somehow harnessed to restore motor control.</span></p><p nodeindex="318" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">But now that the intervention appeared to work in patients with no sensory function, Angeli and colleagues suggested another mechanism.</span></p><p nodeindex="319" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">"Anatomical connections may have persisted after the injury that were previously 'silent' because of loss of conduction as a result of disruption of myelin or the ionic channels of the neurons," they wrote -- connections that were then awakened with the epidural stimulation.</span></p><p nodeindex="320" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Angeli and colleagues indicated that it was conceivable that nerve axons may have regenerated across the lesions, but they called it unlikely, given the quick development of motor control seen with initiation of stimulation in the recent patients.</span></p><p nodeindex="321" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The three new patients -- all victims of motor vehicle accidents -- had to meet strict inclusion criteria. Among them:</span></p><ul nodeindex="323" style="margin-top: 1.5em; margin-bottom: 1.5em; margin-left: 2em; padding-left: 0px;"><li nodeindex="322" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Spinal cord injury at least 1 year previously</span></li><li nodeindex="324" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Stable medical condition without cardiopulmonary or autonomic abnormalities that would prohibit standing or stepping exercises</span></li><li nodeindex="325" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">No infections, fractures, contractures, or other skin or musculoskeletal conditions that could interfere with such training</span></li><li nodeindex="326" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">No clinical depression or substance use disorders</span></li><li nodeindex="327" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">No botulinum toxin injections in the past 6 months</span></li><li nodeindex="328" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Stable spinal cord injury</span></li><li nodeindex="329" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Complete lack of lower-extremity motor response to transcranial magnetic stimulation</span></li><li nodeindex="330" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Sensory evoked potentials either absent or delayed bilaterally</span></li><li nodeindex="331" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">No voluntary ability to induce movement in lower extremities</span></li><li nodeindex="332" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Segmental reflexes retained below the spinal cord lesion</span></li><li nodeindex="333" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">No electromyographic evidence of brain influence on spinal reflexes</span></li></ul><p nodeindex="334" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In fact, all four patients, including Summers, suffered their injuries more than 2 years before starting the stimulation. One was 33 years old, the others were in their 20s. All were male. Injury levels ranged from C6 to T6, with neurological levels from C7 to T5.</span></p><p nodeindex="335" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The three new patients were voluntarily moving their legs and/or feet within 11 days of beginning the epidural stimulation, Angeli and colleagues reported. In one patient, voluntary control appeared in just 4 days. The level of stimulation needed to allow voluntary movements decreased as training continued over several months.</span></p><p nodeindex="336" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">One patient eventually was able to flex his leg without the stimulator being switched on. The others continued to require some stimulation to exert voluntary control.</span></p><p nodeindex="337" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><font color="#000000"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><a href="http://brain.oxfordjournals.org/content/early/2014/04/07/brain.awu038/suppl/DC1" target="_blank" nodeindex="605" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">Videos posted online</a> with the <em nodeindex="606" style="margin: 0px; padding: 0px;">Brain</em> paper showed a patient flexing his left leg vigorously and also rotating one of his feet.</span></font></p><p nodeindex="338" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In addition to the visible leg movements, other measures also confirmed the restoration of motor function. Electromyographic recordings showed essentially no activity in patients' lower bodies without stimulation, but strong responses when the stimulators were turned on.</span></p><p nodeindex="339" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Although standing for short periods became possible, none of the patients has yet regained an ability to walk. On the other hand, Angeli and colleagues reported, "all four of these individuals have found unique ways to incorporate their ability to move their trunk and legs into daily activities."</span></p><p nodeindex="340" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">For example, a video distributed to the media by the University of Louisville showed one patient catching a heavy ball while seated on a table -- clearly using his legs for balance in a way that a truly paraplegic individual could not.</span></p><p nodeindex="341" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Notably, however, the study did not include any blinding or control condition such as sham stimulation in these or other patients.</span></p><p nodeindex="342" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Other limitations included the small number of patients as well as the strict inclusion criteria.</span></p><p nodeindex="343"><p nodeindex="344" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The study was funded principally by the National Institutes of Health and the Christopher and Dana Reeve Foundation, with additional support from the Leona M. and Harry B. Helmsley Charitable Trust, Kessler Foundation, University of Louisville Foundation, and Jewish Hospital and St. Mary's Foundation, Frazier Rehab Institute and University of Louisville Hospital.</span></p><p nodeindex="345" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Study authors have sought patent protection on the use of electrode stimulator arrays for spinal cord injury recovery.</span></p><p> </p></p></div></div></div></div><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-73637151715952005942014-03-27T11:51:00.001-05:002014-03-27T11:51:18.129-05:00Healthcare in the age of Dr. Google: the 2014 digital patient journey<p> <span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;">by</span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;"> </span><a class="RIL_author" href="http://medcitynews.com/author/fathom/" style="-webkit-text-size-adjust: auto; line-height: 1.3em; margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">Fathom</a><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;">,</span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;"> </span><a href="http://medcitynews.com/" style="-webkit-text-size-adjust: auto; line-height: 1.3em; margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">medcitynews.com</a></p><p id="RIL_header" style="padding-bottom: 1.5em;"><cite style="margin: 0px 0px 25px; padding: 0px; position: relative; display: block;"><span class="RIL_date" style="margin: 0px; padding: 0px; display: block; position: absolute; top: 0px; right: 0px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">March 24 06:00 AM</span></span></cite></p><p lang="en"><em nodeindex="386" style="margin: 0px; padding: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br>This post is sponsored by Fathom.</em><p nodeindex="77" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Ask any medical professional what has changed about patient behavior the last few years, and she is sure to talk about a physician who never was accepted to med school … the ubiquitous “Dr. Google.”</span></p><p nodeindex="78" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">When patients start to notice something doesn’t feel quite right, they google their symptoms and make a preliminary diagnosis. In fact, 86 percent of patients conduct a health-related search before scheduling a doctor’s appointment: 90 percent of adults ages 18-24 say they would trust medical information shared by others in their social networks. Forty-one percent say social media impacts their choice of healthcare providers.</span></p><p nodeindex="79" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">These self-diagnosers find a physician with some expertise in their condition and check Google Maps to see who is convenient to their homes or offices. They assume they will end up with a specialist, so they read the local specialist reviews on Vitals and Healthgrades. Think advertising doesn’t matter? Think again: More than 80 percent of health information-seekers will click on a relevant ad.</span></p><p nodeindex="80" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">And the searching continues throughout treatment, with 43 percent of all visits to hospital websites coming from search engines and most patients visiting the sites of two or more hospitals during their investigations.</span></p><p nodeindex="81" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In the waiting room, they post iPad updates on their situations to Twitter and Facebook. Maybe they do some last-minute research; 53 percent of people say that information they found online led them to ask a doctor new questions.</span></p><p nodeindex="82" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">After the doctor visit, they research side effects of prescribed medications. Sixty percent of patients say they research their prescriptions to understand them better—and even decide whether to fill them. They subscribe to a blog on the topic of their condition.</span></p><p nodeindex="83" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">They set up accounts in the physician’s EHR. Then they change social-network profile icons to show support for a cure.</span></p><p nodeindex="84" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">And don’t think “Dr. Google” is only about reaching young patients:</span></p><ul nodeindex="86" style="margin-top: 1.5em; margin-bottom: 1.5em; margin-left: 2em; padding-left: 0px;"><li nodeindex="85" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">67 percent of seniors say that access to their health information is important;</span></li><li nodeindex="87" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">70 percent say they want to be able to request prescription refills electronically;</span></li><li nodeindex="88" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">67 percent want to make online appointments;</span></li><li nodeindex="89" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">58 percent want to email their healthcare providers;</span></li><li nodeindex="90" style="margin-bottom: 0.4em; padding-top: 0px; padding-bottom: 0px; padding-left: 0px; text-align: left;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">and 15 percent want to use a mobile device to manage appointments.</span></li></ul><p nodeindex="91" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Welcome to the digital patient journey.</span></p><p nodeindex="92" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The fact is patients are more involved in their own healthcare than ever before, and the consumption process is now as transparent as car shopping. Seventy-five percent of Americans have conducted a search related to personal health in the last year and more than a third use social media to research health conditions. Half of all patients who use the Internet to self-diagnose ultimately schedule a doctor’s appointment.</span></p><p nodeindex="93" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">What about the doctors?</span></p><p nodeindex="94" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Seventy-eight percent of US doctors are using digital tools to gather research; 70 percent prefer online training to classroom training; and nearly 40 percent communicate with patients online. This is the future of healthcare.</span></p><p nodeindex="95" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Today’s patients are educated, empowered and active. The <a href="http://lp.fathomdelivers.com/digital-patient-journey-registration.html" nodeindex="387" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">marketers’ role</a> is to meet them halfway, ensure access to quality information, and use the new tools to improve the access to and quality of healthcare.</span></p><p nodeindex="96" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Learn more about <a href="http://lp.fathomdelivers.com/digital-patient-journey-registration.html" nodeindex="388" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">healthcare marketing in the age of “Dr. Google.”</a></span></p><a rel="item-license" href="http://medcitynews.com/privacy-policy/" nodeindex="389" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font color="#000000">Copyright 2014 MedCity News. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.</font></a><br></p><p> </p><p> </p><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-17763442741553008632014-03-11T12:53:00.001-05:002014-03-11T12:53:29.716-05:00How a 3D printer helped save life of toddler with congenital heart defects<p id="RIL_header" style="padding-bottom: 1.5em;"><h1 style="margin-top: 0.2em; margin-bottom: 0.5em; padding-bottom: 0.4em; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(221, 221, 221);"><font size="4"><span style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Pediatric innovation: </span></font></h1><cite style="margin: 0px 0px 25px; padding: 0px; position: relative; display: block;"><span class="ril_byline_content" style="margin: 0px; padding: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">by Stephanie Baum, <a href="http://medcitynews.com/" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">medcitynews.com</a></span><span class="RIL_date" style="margin: 0px; padding: 0px; display: block; position: absolute; top: 0px; right: 0px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">March 8th 2014 9:10 AM</span></span></cite></p><p id="RIL_body" style="clear: both;"><div id="RIL_less"><div lang="en"><p nodeindex="90" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The 3D printer has rapidly become something of a medtech superhero. In its latest feat, the technology helped surgeons at Kosair Children’s Hospital in Louisville, Kentucky save a child born with congenital heart defects.</span></p><p nodeindex="91" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">3D printing technology saved the day when pediatric surgeons needed a <a href="http://medcitynews.com/2013/05/michigan-docturs-use-3-d-printed-trachea-splint-to-save-infants-life/" nodeindex="367" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">customized trachea splint when an infant’s trachea collapsed</a>. It’s improved the quality of life for a man <a href="http://medcitynews.com/2013/11/wow-week-3-d-printing-facial-reconstruction-accident-victim/" nodeindex="368" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">injured in a motorcycle accident</a>.</span></p><p nodeindex="92" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">It wasn’t an implant. According to the <a href="http://www.courier-journal.com/article/20140221/NEWS01/302210103/Child-s-heart-fixed-Kosair-Children-s-Hospital-help-3-D-printing" nodeindex="369" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">Courier-Journal</a>, surgeons at the children’s hospital created a model of the heart using flexible rubber, called “Ninja Flex” polymer, to map out how they would navigate the interior parts of the heart of such a young person.</span></p><p nodeindex="96" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Congenital heart defects are the most common types of birth defects. They affect nearly 40,000 infants born in the US each year, <a href="http://www.cdc.gov/features/heartdefects/" nodeindex="370" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">according to data from the Centers for Disease Control</a>.</span></p><p nodeindex="97" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Here’s how it worked.</span></p><p nodeindex="98" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">A radiologist created a 3D image of the boy’s heart by getting cross sections and putting them together on a 3D visual map.</span></p><p nodeindex="99" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">That image was processed through a Maker Bot Replicator with a $2,500 price tag. It was built to be twice the size that was required to make it easier to use as a model and took 20 hours to make. It was also built with three parts to make it easier to go over the procedure.</span></p><p nodeindex="100" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><font color="#000000"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><a href="http://http/medcitynews.com/2013/11/3d-printings-oddest-application-yet-cheaper-better-prosthetic-eyes/" nodeindex="371" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">Eyes</a>, ears, hands and <a href="http://medcitynews.com/2013/07/wow-of-the-week-could-exoskeletal-brace-become-a-disruptive-medical-device/" nodeindex="372" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">reimagining the humble cast</a> with a more flexible brace have all been the subjects of successful 3-D printer work.</span></font></p><p nodeindex="101" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Physicians are just beginning to appreciate the enormous potential of 3D printers not just to reduce healthcare costs but in areas such as pediatrics which although underserved by the medical device market has a particular need for customizable products for young patients. A group of physicians at Children’s Hospital of Philadelphia <a href="http://medcitynews.com/2014/02/pediatic-hospital-physicians-initiate-3d-printing-think-tank/" nodeindex="373" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">formed a think tank</a> to develop applications for 3D printers.</span></p></p></div></div><p><a rel="item-license" href="http://medcitynews.com/privacy-policy/" nodeindex="374" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font color="#000000">Copyright 2014 MedCity News. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.</font></a> </p><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-21299285217552369632014-03-01T15:42:00.001-06:002014-03-01T15:42:11.280-06:00Untitled<p>Google glass is tested in the ER and & OR</p><p> </p><p> http://www.usatoday.com/videos/tech/personal/2014/02/28/5893075/</p><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-83427745773260030572014-02-28T16:31:00.001-06:002014-02-28T16:31:40.571-06:00iWatch May Monitor Heart Rate, Blood Oxygen; Apple Patents Health-Monitoring Headphones<p> <a href="http://iphonelife.com/" style="-webkit-text-size-adjust: auto; line-height: 1.3em; margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">iphonelife.com</a></p><p id="RIL_body" style="clear: both;"><div id="RIL_less"><div lang="en"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br>The torrent of evidence for new products with a focus on health and fitness is astonishing, including a wide range of top experts Apple has hired. According to <em nodeindex="127" style="margin: 0px; padding: 0px;"><a href="http://appleinsider.com/articles/14/02/14/apples-iwatch-rumored-to-use-optoelectronics-to-monitor-heart-rate-blood-oxygen-levels" target="_blank" nodeindex="128" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">AppleInsider</a></em>, a report last week in China's <em nodeindex="129" style="margin: 0px; padding: 0px;">Electrical Engineering Times</em> said that Apple is considering using optoelectronics in their rumored iWatch to monitor pulse and blood oxygen levels. This technology measures the changes in light reflected by the body. Light from small LEDs is projected onto one's finger, for example, and then the sensors measure the amount and color of the light reflected. From this it can determine how fast your heart is beating and how much oxygen saturation there is in your blood. Adding to the credibility of this report is the fact that Apple has hired experts in this area in recent weeks. Whether this technology is slated for an iWatch or other wearable device is unclear, but it appears likely that Apple is developing a product that will use it.</span><p nodeindex="48" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Interestingly, <a href="http://appleinsider.com/articles/14/02/18/apple-patents-sensor-packed-health-monitoring-headphones-with-head-gesture-control" target="_blank" nodeindex="130" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;"><em nodeindex="131" style="margin: 0px; padding: 0px;">AppleInsider</em></a> has also reported that Apple has a new patent for putting health-monitoring sensors in earbuds. The sensors would be able to monitor heart rate, perspiration level, temperature, and other measures. The patent also describes the incorporation of accelerometers that would be able to track the person's movement. In addition, the patent also says the accelerometers could be use to control the earbuds via head gestures. One could, for example, change tracks or adjust the volume of the music. Of course, many technologies described in patents are never developed, so we don't know if we'll actually see something like this. But it's more evidence of Apple's focus on health and fitness along with wearable devices.</span></p><p nodeindex="49" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Other evidence can be seen in various buyout rumors. <em nodeindex="132" style="margin: 0px; padding: 0px;"><a href="http://techcrunch.com/2014/02/16/basis-in-acquisition-talks-with-everyone/" target="_blank" nodeindex="133" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">TechCrunch</a></em> reported on Sunday that Apple is rumored to be among the companies that have been in talks with a smartwatch company called Basis Science, which makes a health-tracking smartwatch. Even more intriguing is the report by <em nodeindex="134" style="margin: 0px; padding: 0px;"><a href="http://www.sfgate.com/news/article/Apple-exploring-cars-medical-devices-to-reignite-5239850.php" target="_blank" nodeindex="135" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">SFGate</a></em> <span nodeindex="136" style="margin: 0px; padding: 0px;">that Apple has had discussions with Elon Musk, the CEO of Tesla, which makes a high-end electric automobile—a meeting that coincided with suggestions by market analysts that Apple buy the company.</span></span></p><p nodeindex="50" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The same report discusses Apple's heavy involvement in exploring medical devices, including a sensor that can predict heart attacks by monitoring the sound blood makes flowing through one's arteries.</span></p><p nodeindex="51" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">All of this strongly indicates Apple is increasingly focused on health and fitness products and on wearable devices. The question is time frame. I'm guessing we won't see anything until late this year at the earliest.</span></p></p></div></div><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-19722961492120397192014-02-26T14:00:00.001-06:002014-02-26T14:00:08.654-06:00Rumor mill: Apple wants to use sensors to detect heart attacks<p> </p><p id="RIL_header" style="padding-bottom: 1.5em;"><cite style="margin: 0px 0px 25px; padding: 0px; position: relative; display: block;"><span class="ril_byline_content" style="margin: 0px; padding: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">by Deanna Pogorelc, <a href="http://medcitynews.com/" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">medcitynews.com</a></span><span class="RIL_date" style="margin: 0px; padding: 0px; display: block; position: absolute; top: 0px; right: 0px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">February 17th 2014</span></span></cite></p><p id="RIL_body" style="clear: both;"><div id="RIL_less"><div lang="en"><div style="text-align: start;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br></span></p><span nodeindex="328" style="margin: 0px; padding: 0px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><div style="text-align: start;"><span nodeindex="328" style="margin: 0px; padding: 0px;">More rumors about the supposed iWatch</span><font> </font><a href="http://www.businessinsider.com/apple-iwatch-to-predict-heart-attacks-2014-2" nodeindex="329" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">emerged this weekend</a><font> </font><span nodeindex="330" style="margin: 0px; padding: 0px;">with reports that Apple is working on technology to detect when someone was about to have a heart attack.</span></div></span><p nodeindex="80" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Reports say that the hardware/software combo, rumored to be spearheaded by a renowned audio engineer from Lucasfilm, would listen to the sound of blood flowing through the wrist. If the software would detect that an artery was clogged with plaque, the watch would issue an alert.</span></p><p nodeindex="84" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">The idea may sound great, but like <a href="http://medcitynews.com/2014/01/accuracy-cost/" nodeindex="331" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">Google’s would-be contact lens for diabetes</a>, it’s hard to imagine it becoming a reality any time soon.</span></p><p nodeindex="85" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Cholesterol levels, blood pressure and lifestyle factors can give doctors an indication of a person’s risk of heart attack, but actually predicting one when it’s about to happen is a different story.</span></p><p nodeindex="86" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Not surprisingly, Apple isn’t even close to being the first one to think of it.</span></p><p nodeindex="87" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Recent efforts for such technology include Swiss researchers who made a splash last year when they <a href="http://www.theverge.com/2013/3/19/4125148/blood-test-implant-uses-bluetooth-detects-heart-attacks-early" nodeindex="332" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">introduced an implantable chip</a> they were working on to monitor molecules in the blood to detect heart attacks hours before they happen. Scripps Health <a href="http://www.mddionline.com/article/qualcomm-and-scripps-join-forces-usher-medicine-21st-century" nodeindex="333" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">got a grant from Qualcomm</a> in 2012 to conduct clinical trials of a similar nanosensor device.</span></p><p nodeindex="88" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">On the noninvasive side of things, professors at Stanford University <a href="http://www.gizmag.com/micro-sensor-heart-monitoring/27555/" nodeindex="334" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">prototyped a wearable pressure sensor the size of a stamp</a> that they say can monitor the two peaks of pulse waves, which might be helpful in monitoring heart health. A company called iHealth is also <a href="http://medcitynews.com/2013/12/ihealth-smart-cuff-medical-device-may-save-heart-attack/" nodeindex="335" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">reportedly working with cardiologists on a modified blood pressure cuff</a> that would monitor <a href="http://www.cedars-sinai.edu/Patients/Programs-and-Services/Womens-Heart-Center/Services/Endothelial-Function-Testing.aspx" nodeindex="336" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">endothelial function</a> as an indicator of heart attack or stroke. Then there’s <a href="http://aumcardio.com/" nodeindex="337" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">AUM Cardiovascular</a>, which is <a href="http://medcitynews.com/2010/01/shhhh-do-you-hear-that-that-sounds-like-a-heart-attack/" nodeindex="338" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">developing an acoustic device that primary care doctors</a> would use to check for blockage in the coronary artery.</span></p><p nodeindex="89" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">But none of these technologies has made it to the market yet.</span></p><p nodeindex="90" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">One shimmer of hope for Apple lies in stories about how physicians using the mobile ECG app AliveCor have been able to <a href="http://medcitynews.com/2012/12/beta-tester-did-diagnosis-on-the-fly-with-alivecor-iphone-heart-monitor/" nodeindex="339" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">diagnose heart conditions on the fly</a>. But being able to learn about arteries through the skin, and develop algorithms that function like a doctor to identify when something’s awry, would be a big leap.</span></p><p nodeindex="91" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Other, more realistic rumored features of the iWatch include <a href="http://medcitynews.com/2013/12/apple-patents-hover-touch-sensor-heart-rate-monitor-smartphones/" nodeindex="340" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">an integrative heart rate sensor</a> and an <a href="http://www.stuff.tv/apple/apple-iwatch/review" nodeindex="341" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">app that would track blood pressure, heart rate and hydration levels</a>.</span></p><a rel="item-license" href="http://medcitynews.com/privacy-policy/" nodeindex="342" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font color="#000000">Copyright 2014 MedCity News. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.</font></a></div></div></div><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-79251975822594883212014-02-23T16:12:00.001-06:002014-02-23T16:12:27.263-06:00A digital device in pivotal trials listens for the sound of a potential heart attack in the making<p><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;">by Deanna Pogorelc,</span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;"> </span><a href="http://medcitynews.com/" style="-webkit-text-size-adjust: auto; line-height: 1.3em; margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">medcitynews.com</a><br></p><p id="RIL_header" style="padding-bottom: 1.5em;"><cite style="margin: 0px 0px 25px; padding: 0px; position: relative; display: block;"><span class="RIL_date" style="margin: 0px; padding: 0px; display: block; position: absolute; top: 0px; right: 0px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">February 18th 2014 4:07 PM</span></span></cite></p><p id="RIL_body" style="clear: both;"><div id="RIL_less"><div lang="en"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><br>For Marie Johnson, coming up with a better way to detect coronary artery disease is both a business and a personal mission.</span><p nodeindex="77" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Johnson is CEO of <a href="http://aumcardio.com/" nodeindex="228" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">AUM Cardiovascular</a>, a Minnesota medical device company that’s developing a potentially cheaper, simpler, eight-minute test to detect signs of coronary artery disease — the primary cause of heart attack.</span></p><p nodeindex="78" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">In a clinical study under way, the company is putting its Cadence device head-to-head against <a href="http://www.nlm.nih.gov/medlineplus/ency/article/007201.htm" nodeindex="229" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">nuclear stress testing</a> with the hope of showing that it’s just as effective at detecting obstructive coronary artery disease. If it can show that, Johnson expects to be able to launch the device in Europe in the second half of this year and in the U.S. next fall.</span></p><p nodeindex="79" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Johnson lost her 41-year-old husband to an unexpected heart attack in 2009. Although he was seemingly healthy, the autopsy revealed that several of his coronary arteries were blocked and that a plaque had ruptured in the left anterior descending vessel of his heart. Blockage in this vessel, nicknamed “<a href="http://en.wikipedia.org/wiki/Widow_maker" nodeindex="230" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">the widowmaker,</a>” is particularly associated with mortality.</span></p><p nodeindex="83" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Coincidentally, at the time, Johnson had been working with 3M scientists to develop a <a href="http://solutions.3m.com/wps/portal/3M/en_WW/Littmann_3100_3200/stethoscope/" nodeindex="231" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">computerized stethoscope</a> as part of her PhD program and had used the prototype device to collect hundreds of data points from the sound of her husband’s heart just a few months before.</span></p><p nodeindex="84" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">That served as a launching pad for Johnson to begin developing <a href="http://medcitynews.com/2010/01/shhhh-do-you-hear-that-that-sounds-like-a-heart-attack/" nodeindex="232" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">a system comprising sensors and algorithms</a> that could identify a certain acoustic signature associated with blockage of the coronary arteries. A small acoustic device about the size of an egg is pressed against a few different points on the chest. It uses sensors to listen for turbulence in blood flow through coronary vessels that suggest they could be blocked.</span></p><p nodeindex="85" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">“The device is pretty simple – there are some advanced algorithms associated with noise and signal capture, but the real juice is in the algorithm where we analyze the data to provide the doctor with a reading of normal, diseased or inconclusive,” Johnson said.</span></p><p nodeindex="86" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">When plaque buildup on the inner walls of the arteries reaches a certain point, patients may become a candidate <a href="http://www.scai.org/SecondsCount/Disease/CoronaryArteryDisease/Treatment.aspx" nodeindex="233" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">for some kind of intervention</a> to prevent worsening of the disease and heart attack. Johnson said AUM’s test can’t tell doctors exactly which vessel the blockage is in, but can give them an indication of whether further interrogation is warranted.</span></p><p nodeindex="87" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">For the <a href="http://clinicaltrials.gov/ct2/show/NCT01743040?term=AUM+Cardiovascular&rank=2" nodeindex="234" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none;">pivotal trial that’s going on now</a>, the company is collecting data from 729 patients who present in one of 15 sites with chest pain and also have two or more coronary risk factors. They’re being tested with AUM’s device and with a nuclear stress test, a method of imaging that shows how blood is flowing into the heart.</span></p><p nodeindex="88" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">“We can’t do everything that a nuclear stress test can do, but what we’re saying is that we’re not inferior in detecting obstructive coronary artery disease,” Johnson said.</span></p><p nodeindex="89" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">A nuclear stress test costs on average somewhere around $1,000, Johnson explained, involves the use of a radiopharmaceutical and can take up to three hours. AUM’s device, she said, would have a price point around $200 per test and would deliver results in about eight minutes.</span></p><p nodeindex="90" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Data collection for the trial should wrap up by December, Johnson said, with a filing for FDA clearance likely to follow around this time next year, if all goes well. But first, AUM will tackle commercialization in Europe. Johnson expects the device to get CE Mark by July and launch in 10 centers in Europe by the end of the year.</span></p><p nodeindex="91" style="text-align: start; margin-bottom: 1em; -webkit-hyphens: auto;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">She said the company, which was formed in 2009 and now has six full-time staffers, will be raising a round of funding to support the European launch soon.</span></p><a rel="item-license" href="http://medcitynews.com/privacy-policy/" nodeindex="236" style="margin: 0px; padding: 0px; cursor: pointer; text-decoration: none; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font color="#000000">Copyright 2014 MedCity News. </font></a></p></div></div><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-51412388231698259732014-01-31T19:39:00.001-06:002014-01-31T19:39:02.160-06:00Rumor: Apple's next-gen iOS 8 to include 'Healthbook' app for comprehensive health monitoring<p> <span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;">By:</span><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; line-height: 1.3em;"> </span><a href="mailto:mikeycampbell@gmail.com" style="-webkit-text-size-adjust: auto; line-height: 1.3em; text-decoration: none;">Mikey Campbell</a></p>
<p class="post-body entry-content" id="post-body-5753514674947464378" itemprop="description articleBody" style="width: 578px; position: relative;"><p class="datePublished"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Friday, January 31, 2014 7:18 PM</span></p>
<p class="body"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><span class="article-leader">A report on Friday claims Apple is working to incorporate a new built-in app dubbed "Healthbook" into its next iOS iteration, with the software able to track everything from food intake to glucose levels. </span><br>
<br>
Citing sources familiar with the plans, <em>9to5Mac</em> claims the codenamed "Healthbook" will be able <a href="http://9to5mac.com/2014/01/31/iwatch-ios-8-apple-sets-out-to-redefine-mobile-health-fitness-tracking/" style="text-decoration: none;">tap into data</a> from advanced sensors possibly built into next-generation iOS devices -- including the so-called "iWatch" -- to track a variety of metrics via a swipe-able card UI. <br>
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On the health side, "Healthbook" can reportedly track blood pressure, hydration level, heart rate and even glucose level measurements. As for blood readings, Apple's <a href="appleinsider://appleinsider.com/mobile/apps/ipad/news/25932" style="text-decoration: none;">recent hire</a> of Michael O'Reilly may play an integral role in the development of such technology. Prior to joining Apple, O'Reilly was the chief medical officer and executive vice president of medical affairs at pulse oximeter firm Masimo Corporation.<br>
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In addition to data aggregation, the app may have hooks into other first-party software like Calendar and Reminders, allowing users to create medication reminders. In its final form, "Healthbook" could be a one-stop solution for nearly all things medical. <br>
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As for fitness, the app is said to include the usual steps taken and distance measurement data, while adding in daily caloric intake and weight tracking.<br>
<br>
Perhaps the most interesting implication of an app like "Healthbook" is the hardware needed to generate raw data -- hardware that does not yet exist in Apple's ecosystem. Currently, Apple's<a href="appleinsider://appleinsider.com/mobile/apps/ipad/news/24571" style="text-decoration: none;">M7 motion coprocessor</a> allows for accurate measurement of step and distance traveled, but falls short of physical body readings like those purportedly coming with the new app. <br>
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One answer would be the intorduction of a peripheral device, such as a watch, that incorporates advanced components like a thermometer, galvanic skin response sensor, blood oximeter and more. Data can then be offloaded to an iPhone via Bluetooth, processed and recorded. <br>
<br>
Apple's timeline for a rollout of the supposed app and corresponding hardware is largely unknown, but it can be expected that a next-generation iOS and iPhone will be released as per the company's usual annual product cycle. <br>
<br>
Adding fuel to the rumor fire, a <em>The New York Times</em> report on Friday noted Apple SVP of Operations Jeff Williams, VP of Software and Technology Bud Tribble, Michael O'Reilly and government affairs counsel Tim Powderly <a href="appleinsider://appleinsider.com/mobile/apps/ipad/news/25944" style="text-decoration: none;">met with</a> the FDA in December to discuss "mobile medical applications." The nature and outcome of the meet-up remains unknown.</span></p>
</p><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0tag:blogger.com,1999:blog-7446720573412095016.post-31204231122063165072014-01-29T16:13:00.001-06:002014-01-29T16:13:41.965-06:00Delete Emails from Server when Deleted on iPhone or iPad<p> <a href="zite://opentopic/?loglocation=sourceheader&bookmarked=false&liked=false&name=trickyways.com&issource=true&id=trickyways.com" style="margin: 0px; padding: 0px; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none; text-decoration: none;"><span class="source" style="margin: 0px; padding: 0px; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);"><font color="#000000"><img src="http://www.google.com/s2/favicons?domain=www.trickyways.com" id="blogsy-1391033551131.3901" class="" alt="" width="16" height="16"> TRICKYWAYS.COM</font></span></a></p>
<p id="topbar" style="margin-top: 38px; border-width: 0px 0px 1px; border-bottom-style: solid; border-bottom-color: rgb(229, 229, 229); outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none; width: 764px; -webkit-box-shadow: white 0px 1px 0px; height: 19px;"><span class="ago" style="margin: 0px; padding: 0px; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none; float: right; position: relative; top: 3px;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">2 Hours Ago</span></span></p>
<h1 style="margin-top: 40px; padding-bottom: 0px; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none; text-shadow: none; font-weight: 500;"><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; font-size: 18px; line-height: 1.3em;">When you have limited quota for your email address on mail server then you must frequently delete emails from server. If you iPad or iPhone user and set up email address on the device then you must set option to delete emails from server once you download and delete unwanted emails on your iPhone or iPad.</span><br>
</h1>
<p style="margin-top: 1.5em; margin-bottom: 1.5em; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none;"><div style="border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none;"><p style="margin-top: 1.5em; margin-bottom: 1.5em; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">While <a href="http://www.trickyways.com/2010/04/setup-an-email-on-ipad/" style="margin: 0px; padding: 0px; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: default; text-decoration: none;">setting up email on iPad</a> or iPhone iOS gives option to setup account as POP3 or IMAP, for both of types, settings to delete emails from server is different. So checkout how to set Mail app to delete messages from server on iPad or iPhone.</span></p>
<h3 style="margin-top: 1.5em; margin-bottom: 1.5em; padding-bottom: 0px; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none; font-weight: 500;"><font size="4"><span style="line-height: 23px; -webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Delete email from Server POP3 Account</span></font></h3>
<p style="margin-top: 1.5em; margin-bottom: 1.5em; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">To delete emails from server your need to change few settings in Mail app on iPhone or iPad. Open Settings app on your device and then tap “mail, Contacts, Calendars” option, here under Accounts section tap on your email account. Scroll-down a bit and tap on “Advanced” option</span></p>
<p style="margin-top: 1.5em; margin-bottom: 1.5em; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Under “Incoming Settings” section tap the “Delete from server option” and choose an option.</span></p>
<p style="margin-top: 1.5em; margin-bottom: 1.5em; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">I preferred to delete emails after 7 days, you can choose different options to delete email from server according to your requirements. To save these advanced email settings tap the “Advanced” arrow button on top-left side of title, tap once again and then tap “Done” button on the right side.</span></p>
<p style="margin-top: 1.5em; margin-bottom: 1.5em; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none;"><span style="background-color: rgba(255, 255, 255, 0); -webkit-text-size-adjust: auto; font-size: large;">Delete mail from Server IMAP Account</span><br>
</p>
<p style="margin-top: 1.5em; margin-bottom: 1.5em; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">If you setup your email as an IMAP then you will see different advanced settings for your email on iPhone or iPad.</span></p>
<p style="margin-top: 1.5em; margin-bottom: 1.5em; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Follow this path to open advanced settings and set Mail options to delete emails from server, open Settings > Mail, Contacts, Calendars. Tap on your account name and then tap on email account under IMAP section, Here tap the “Advanced” option.</span></p>
<p style="margin-top: 1.5em; margin-bottom: 1.5em; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Now tap the “Deleted Mailbox” and choose Trash under the “On the Server” section. It means when you delete any email from Mail app on iPhone or iPad this will goes to the trash folder (<a href="http://www.trickyways.com/2013/11/hide-mailboxes-ios-7/" style="margin: 0px; padding: 0px; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: default; text-decoration: none;">Mailbox</a>) on your server. This mail’s trash folder available on the server is synced with your device and whenever you delete emails from trash folder on device it will also delete messages from web server.</span></p>
<p style="margin-top: 1.5em; margin-bottom: 1.5em; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Tip: you can also choose folders (Mailboxes) for Drafts and Sent email, so every time when you compose an email or sent mail to someone this will be available on your server as well. This way you can easily access your drafts and sent emails on any other device or computer.</span></p>
<p style="margin-top: 1.5em; margin-bottom: 1.5em; border: 0px; outline: rgb(0, 0, 0); vertical-align: baseline; -webkit-touch-callout: none;"><span style="-webkit-text-size-adjust: auto; background-color: rgba(255, 255, 255, 0);">Do you able to solve your problem, or have and question? please tell us below in comments.</span></p>
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</div><p> </p><div style="text-align: right; font-size: small; clear: both;" id="blogsy_footer"><a href="http://blogsyapp.com" target="_blank"><img src="http://blogsyapp.com/images/blogsy_footer_icon.png" alt="Posted with Blogsy" style="vertical-align: middle; margin-right: 5px;" width="20" height="20" />Posted with Blogsy</a></div>Anonymoushttp://www.blogger.com/profile/11274923083374071218noreply@blogger.com0